Data report on inflammatory C–C chemokines among insulin-using women with diabetes mellitus and breast cancer

Wintrob, Zachary A.P.; Hammel, Jeffrey; Nimako, George K.; Fayazi, Zahra; Gaile, Dan P.; Davis, Erin E.; Forrest, Alan; Ceacareanu, Alice C.

doi:10.1016/j.dib.2017.02.045

Cited by 3 publications

(3 citation statements)

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“…Similar observations linking increased fasting insulin level with cancer death have been reported in other studies [22]. In recent publications Wintrob et al [23,24] have shown that exogenous insulin prompts TH1 and TH2 helper cells to produce proinflammatory cytokines and activates tumor associated macrophages. Accordingly, maintaining chronic inflammation supplies a suitable milieu for cancer development.…”

Section: Discussionsupporting

confidence: 74%

About the Role of Insulin in the Interaction Between Human Immune and Colon Cancer Cells

Djaldetti¹

2017

Arch Microbiol Immunology

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Background: Insulin has been one of the immense contributions to human health. Besides its role in treatment of diabetes, insulin affects inflammatory cytokine production, chronic inflammation and cancer development. We have examined the effect of insulin on cytokine production by human peripheral blood mononuclear cells (PBMC) and its role in the balance between immune and human colon cancer cells.Methods: Human LPS stimulated and non-stimulated PBMC, HT-29 and RKO cancer cell lines were separately incubated with insulin at various concentrations and the production of TNFα, IL-1, IL-6, IFNγ, IL-1ra and IL-10 was examined. In addition, the effect of insulin on the secretion of these cytokines by PBMC co-incubated with carcinoma cells was evaluated.Results: Insulin added to non-stimulated PBMC caused a decreased secretion of the pro-inflammatory TNFα.Stimulation of PBMC with either LPS or PMA resulted in decreased production of IL-1β, TNFα and IFNγ and an increased generation of IL-6. The production of the anti-inflammatory cytokine IL-10 was elevated by both stimulated and unstimulated PBMC. Insulin added to PBMC inhibited the secretion of IFNγ stimulated with both HT-29 and RKO cells and reduced TNFα production induced by RKO cells. Conclusions:The results indicate that insulin interferes with inflammatory cytokine production by stimulated PBMC and it affects the cross talk between immune and colon cancer cells. It appears that the effect of insulin on

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Section: Discussionsupporting

confidence: 74%

About the Role of Insulin in the Interaction Between Human Immune and Colon Cancer Cells

Djaldetti¹

2017

Arch Microbiol Immunology

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“…Some of such areas are: CT images, growth factor levels in incident breast cancer, hormone receptor status, cytokine circulation, secretagogue users in breast cancer treatments, chemokine levels, breast cancer and diabetes mellitus co-infection and treatment, breast cancer and HIV treatment, breast cancer and pregnancy. Others are: proteome analysis, risk factors analysis, breast examination, screening, management and breast cancer awareness, epidemiology, risk assessment tools, treatment options: radiotherapy treatment versus chemotherapy, survival analysis, breast cancer subtypes, biomarkers, socio-cultural barriers to treatment, socio-demographic factors and alternative medicine approach, genetic risk, dietary patterns, early diagnostics and treatment and others [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Breast cancer patients in Nigeria: Data exploration approach

2017

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Breast cancer is the type of cancer that develops from breast tissue; it is mostly common in women and it is one of the most studied diseases, largely because of its high mortality (second to lung cancer). However, it occurs in males also. This article presents a statistical study of the distribution of age, gender, length of stay, mode of diagnosis, status (dead or alive) after treatment and the location of breast cancer among 300 patients admitted in the University of Ilorin teaching hospital, Ilorin, Nigeria. The study covers a period of five (5) years; from 2011 to 2016 and logistic regression was used to perform the basic analysis in this study. It was discovered that the age of patients and the location of the breast cancer (right or left) contributes significantly to the survival of the patients. However, early detection and treatment of the disease is highly encouraged. This study also recommends that awareness should be taken to the grassroots and males should not be excluded from this discussion.

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“…Characterization of the underlying mechanisms regulating immune infiltration in breast tumors can elucidate the key determinants for a successful host anti-tumor immune response. Secretion of chemokines within the tumor microenvironment and how certain co-morbidities like diabetes can affect the tumor chemokine milieu have gained attention as important factors that shape tumor lymphocyte infiltration [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes

Prabhakaran

Rizk

et al. 2017

Breast Cancer Res

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BackgroundA unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal cancer and metastatic melanoma. We analyzed the correlation between CS, clinicopathological variables, molecular data, and 366 survival in Moffitt Cancer Center’s Total Cancer Care (TCC) patients with non-metastatic breast cancer.MethodsAffymetrix gene expression profiles were used to interrogate the CS by the principal component method. Breast tumors were classified as high or low score based on median split, and correlations between clinicopathologic variables, PAM50 molecular subtype, and ELN formation were analyzed using the TCC dataset. Differences in overall survival (OS) and recurrence-free survival (RFS) in the larger KM Plot breast cancer public datasets were compared using Kaplan-Meier curves.ResultsWe divided the Total Cancer Care (TCC) breast cancer patients into two groups of high or low CS. Mean CS was 0.24 (range, 2.2–2.1). Patients with higher CS were more likely to be white (172 vs. 159; p = 0.03), had poorly differentiated tumors (112 vs. 59; p <0.0001), ER/PR negative (41 vs. 26) and HER2 positive (36 vs. 19; p = 0.001), and contain TL-ELNs. Higher CS scores were also seen in the basal and HER2+ molecular subtypes. In the KM Plot breast cancer datasets higher CS patients demonstrated superior OS (HR = 0.73, p = 0.008) and RFS (HR 0.76, p = <0.0001), especially in basal and HER2+ patients.ConclusionsHigh CS breast tumors tend to be higher grade, basal or HER2+, and present more frequently in Caucasians. However, this group of patients also shows the presence of TL-ELNs within the tumor microenvironment and has better survival outcomes. The CS is a novel tool that can identify breast cancer patients with tumors of a unique intratumoral immune composition and better prognosis. Whether or not the CS is a predictive response marker in breast cancer patients undergoing immunotherapy remains to be determined.Electronic supplementary materialThe online version of this article (doi:10.1186/s13058-017-0864-z) contains supplementary material, which is available to authorized users.

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Data report on inflammatory C–C chemokines among insulin-using women with diabetes mellitus and breast cancer

Cited by 3 publications

References 6 publications

About the Role of Insulin in the Interaction Between Human Immune and Colon Cancer Cells

About the Role of Insulin in the Interaction Between Human Immune and Colon Cancer Cells

Breast cancer patients in Nigeria: Data exploration approach

Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes

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