The USAID funded Twiyubake program applied a dual systems and family-centered approach to provide a comprehensive package of services that aimed to strengthen the capacity and resilience of the targeted vulnerable families/households. The program built upon and strengthened existing community care structures to deliver and sustain high quality services to the enrolled households including economic strengthening, health promotion, water sanitation and hygiene etc. The Household Vulnerability and Graduation Assessment was used by Twiyubake program to determine household capacity to graduate from direct program assistance. The dataset used in this study came from the Twiyubake program’s annual monitoring data. Five different machine learning classification models namely Logistic Regression, Random Forest, Gaussian Naive Bayes, K-Nearest Neighbors, and Multi-Layer Perceptron, were used to build a predictive model of household capacity to graduate. The performance of predictive models was assessed using a variety of metrics, including the confusion matrix, accuracy, precision, recall, F1 score, and the Area under the Receiver Operating Characteristics. The results showed that the Random Forest model correctly predicted household graduation capacity with 94.8 percent of the accuracy, with recall score of 94.8 percent, precision score of 94.8 percent, and F1 score of 94.8 percent. Overall, all the machine learning algorithms performed very well with over 85 percent performance on the different evaluation parameters used. The Random Forest model was recommended as the best household graduation prediction classifier for the Twiyubake program since it performed better than the rest.