Data Set for the Reporting of Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

Gilks, C. Blake; Selinger, Christina; Davidson, Ben; Köbel, Martin; Ledermann, Jonathan A.; Lim, Daryl; Malpica, Anaís; Mikami, Yoshiki; Singh, Naveena; Srinivasan, Radhika; Vang, Russell; Lax, Sigurd; McCluggage, W. Glenn

doi:10.1097/pgp.0000000000000908

Cited by 14 publications

(11 citation statements)

References 192 publications

(331 reference statements)

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“…23 These changes in practice are also reflected in changes to the International Collaboration on Cancer Reporting recommendations in 2015 and 2022. 24 As societal awareness of the tubal origin theory was incorporated into the practice of pathology, there was an increase in propensity to diagnose a tubal carcinoma as opposed to an ovarian carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis Shift in Site of Origin of Tubo-Ovarian Carcinoma

Lee,

Anderson,

Girma

et al. 2024

Obstetrics &Amp; Gynecology

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OBJECTIVE: To assess population-level trends, characteristics, and outcomes of high-grade serous tubo-ovarian carcinoma in the United States. METHODS: This retrospective cohort study queried the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. The study population was 27,811 patients diagnosed with high-grade serous tubo-ovarian carcinoma from 2004 to 2020. The exposure was the primary cancer site (ovary or fallopian tube). Main outcome measures were temporal trends, clinical characteristics, and overall survival associated with primary cancer site assessed in multivariable analysis. RESULTS: The study population comprised 23,967 diagnoses of high-grade serous ovarian carcinoma and 3,844 diagnoses of high-grade serous fallopian tubal carcinoma. The proportion of diagnoses of high-grade serous fallopian tubal carcinoma increased from 365 of 7,305 (5.0%) in 2004–2008 to 1,742 of 6,663 (26.1%) in 2017–2020. This increase was independent in a multivariable analysis (adjusted odds ratio [aOR] vs 2004–2008, 2.28 [95% CI, 1.98–2.62], 3.27 [95% CI, 2.86–3.74], and 6.65 [95% CI, 5.84–7.57] for 2009–2012, 2013–2016, and 2017–2020, respectively). This increase in high-grade serous fallopian tubal carcinoma was seen across age groups (4.3–5.8% to 22.7–28.3%) and across racial and ethnic groups (4.1–6.0% to 21.9–27.5%) (all P for trend <.001). Among the cases of tumors smaller than 1.5 cm, the increase was particularly high (16.9–67.6%, P for trend <.001). Primary-site tumors in the high-grade serous fallopian tubal carcinoma group were more likely to be smaller than 1.5 cm (aOR 8.26, 95% CI, 7.35–9.28) and unilateral (aOR 7.22, 95% CI, 6.54–7.96) compared with those in high-grade serous ovarian carcinoma. At the cohort level, the diagnosis shift to high-grade serous fallopian tubal carcinoma was associated with narrowing differences in survival over time between the two malignancy groups: adjusted hazard ratio 0.84 (95% CI, 0.74–0.96), 0.91 (95% CI, 0.82–1.01), 1.01 (95% CI, 0.92–1.12), and 1.12 (95% CI, 0.98–1.29) for 2004–2008, 2009–2012, 2013–2016, and 2017–2020, respectively. CONCLUSION: This population-based assessment suggests that diagnoses of high-grade serous tubo-ovarian carcinoma in the United States have been rapidly shifting from high-grade serous ovarian to fallopian tubal carcinoma in recent years, particularly in cases of smaller, unilateral tumors.

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Section: Discussionmentioning

confidence: 99%

Diagnosis Shift in Site of Origin of Tubo-Ovarian Carcinoma

Lee,

Anderson,

Girma

et al. 2024

Obstetrics &Amp; Gynecology

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“…Since clinically aggressive tumors can have a misleadingly low-grade histologic appearance, grading such tumors may not be relevant and, instead, the tumors should be regarded intrinsically high grade Pathology of the Lower 14 . This will be endorsed in the upcoming update of the International Collaboration on Cancer Reporting (ICCR) guide for Ovarian, fallopian tube, and primary peritoneal carcinomas Pathology of the Lower 15 .…”

Section: Discussionmentioning

confidence: 99%

Ovarian RASoma With Mesonephric-like Adenocarcinoma and Mixed Mullerian Components: A Case Report With Molecular Analysis Demonstrating Multidirectional Mullerian Differentiation

Stolnicu

Bartalis²,

Ye³

et al. 2023

International Journal of Gynecological Pathology

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Gynecologic carcinomas with RAS mutations may show a wide spectrum of histologic types, including mixed types. We present the case of a 63-yr-old patient diagnosed with an ovarian tumor harboring a mesonephric-like adenocarcinoma in a background of mixed mesonephric-like, mucinous, and endometrioid components. Molecular analysis revealed that all 3 components shared the same clonal KRAS mutation (p.G12A) and chromosome 1q gain. Based on shifts in clonality, copy number gains, and acquisition of an additional mutation, our data suggest that the mucinous component likely constituted the substrate from which the mesonephric-like and endometrioid components arose.

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“…The same criteria were applied for cases that were not part of previous studies. Grade was reviewed on representative slides using the Silverberg and FIGO systems 21,22 . Specimens for all cohorts were represented on previously constructed tissue microarrays with triplicate (AOVT) or duplicate cores of 0.6 mm in diameter.…”

Section: Methodsmentioning

confidence: 99%

Infiltrative pattern of invasion is independently associated with shorter survival and desmoplastic stroma markers FAP and THBS2 in mucinous ovarian carcinoma

Köbel,

Kang,

Lee

et al. 2023

Histopathology

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AimsMucinous ovarian carcinoma (MOC) is a rare ovarian cancer histotype with generally good prognosis when diagnosed at an early stage. However, MOC with the infiltrative pattern of invasion has a worse prognosis, although to date studies have not been large enough to control for covariables. Data on reproducibility of classifying the invasion pattern are limited, as are molecular correlates for infiltrative invasion. We hypothesized that the invasion pattern would be associated with an aberrant tumour microenvironment.Methods and resultsFour subspecialty pathologists assessed interobserver reproducibility of the pattern of invasion in 134 MOC. Immunohistochemistry on fibroblast activation protein (FAP) and THBS2 was performed on 98 cases. Association with survival was tested using Cox regression. The average interobserver agreement for the infiltrative pattern was moderate (kappa 0.60, agreement 86.3%). After reproducibility review, 24/134 MOC (18%) were determined to have the infiltrative pattern and this was associated with a higher risk of death, independent of FIGO stage, grade, and patient age in a time‐dependent manner (hazard ratio [HR] = 10.2, 95% confidence interval [CI] 3.0–34.5). High stromal expression of FAP and THBS2 was more common in infiltrative MOC (FAP: 60%, THBS2: 58%, both P < 0.001) and associated with survival (multivariate HR for FAP: 1.5 [95% CI 1.1–2.1] and THBS2: 1.91 [95% CI 1.1–3.2]).ConclusionsThe pattern of invasion should be included in reporting for MOC due to the strong prognostic implications. We highlight the histological features that should be considered to improve reproducibility. FAP and THBS2 are associated with infiltrative invasion in MOC.

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Data Set for the Reporting of Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

Cited by 14 publications

References 192 publications

Diagnosis Shift in Site of Origin of Tubo-Ovarian Carcinoma

Diagnosis Shift in Site of Origin of Tubo-Ovarian Carcinoma

Ovarian RASoma With Mesonephric-like Adenocarcinoma and Mixed Mullerian Components: A Case Report With Molecular Analysis Demonstrating Multidirectional Mullerian Differentiation

Infiltrative pattern of invasion is independently associated with shorter survival and desmoplastic stroma markers FAP and THBS2 in mucinous ovarian carcinoma

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