Data sources for in vivo molecular profiling of human phenotypes

Abstract

Molecular profiling of human diseases has been approached at the genetic (DNA), expression (RNA), and proteomic (protein) levels. An important goal of these efforts is to map observed molecular patterns to specific, mechanistic organic entities, such as loci in the genome, individual RNA molecules or defined proteins or protein assemblies. Importantly, such maps have been historically approached in the more intuitive context of a theoretical individual cell, but diseases are better described in reality using an in vivo framework, namely a library of several tissue-specific maps. In this article, we review the existing data atlases that can be used for this purpose and identify critical gaps that could move the field forward from cellular to in vivo dimensions. WIREs Syst Biol Med 2016, 8:472-484. doi: 10.1002/wsbm.1354 For further resources related to this article, please visit the WIREs website.

Druggability of Targets for Diagnostic Radiopharmaceuticals

“…37 Analysis of the 44 common tissues in the HPA database reveals that human GLUT1 (gene SLC2A1) exhibits elevated protein expression levels solely in select tissues, including the cerebral cortex, kidney, placenta, skin, and tonsil (www.proteinatlas.org/ENSG00000117394-SLC2A1). 38 Conversely, protein expression levels in other tissues are low. The exceptional specificity of GLUT1 as a diagnostic target for tumors is evident, making it an ideal candidate for a range of cancer diagnoses, including lung cancer, breast cancer, colorectal cancer, lymphoma, melanoma, head and neck cancers, esophageal cancer, gastrointestinal stromal tumors, pancreatic cancer, and ovarian cancer.…”

“…Cancer cells often overexpress GLUT1 to meet their increased energy demands, which leads to an increased uptake of 18 F-FDG in these cells . Analysis of the 44 common tissues in the HPA database reveals that human GLUT1 (gene SLC2A1) exhibits elevated protein expression levels solely in select tissues, including the cerebral cortex, kidney, placenta, skin, and tonsil () . Conversely, protein expression levels in other tissues are low.…”