Data Storage Using DNA

Abstract

The exponential growth of global data has outpaced the storage capacities of current technologies, necessitating innovative storage strategies. DNA, as a natural medium for preserving genetic information, has emerged as a highly promising candidate for next‐generation storage medium. Storing data in DNA offers several advantages, including ultra‐high physical density and exceptional durability. Facilitated by significant advancements in various technologies, such as DNA synthesis, DNA sequencing, and DNA nanotechnology, remarkable progress has been made in the field of DNA data storage over the past decade. However, several challenges still need to be addressed to realize practical applications of DNA data storage. In this review, we first introduce the processes and strategies of in vitro DNA data storage, highlighting recent advancements. Next, we provide a brief overview of in vivo DNA data storage, with a focus on the various writing strategies developed to date. Lastly, we summarize the challenges encountered in each step of DNA data storage and discuss promising techniques that hold great promise in overcoming these obstacles.This article is protected by copyright. All rights reserved

Two-Dimensional Lanthanide Metal–Organic Framework Heterostructures for Noninvasively Photoresponsive High-Security Photonic Barcodes

“…Micro/nanoscale photonic barcodes with high concealment hold great potential for item tracking, biomedical imaging, and information security. − The ever-increasing demand for high-security levels in the field of anticounterfeiting necessitates micro/nanoscale barcodes that demonstrate accurate identification, high encoding capacity, and multiple authentication capabilities. − Transforming photoluminescence (PL) properties into specific spectral recognition codes is considered as a basic principle for designing novel micro/nanoscale photonic barcodes. − Luminescent metal–organic frameworks (MOFs) simultaneously possess high stability of inorganic materials and excellent processability of organic materials, which thus have emerged as robust photonic barcode platforms. − Especially, lanthanide (Ln) ions are widely believed to be ideal emitting sources of MOFs due to their unique narrow-line emission characteristics with a series of well-resolved peaks and the favorable lattice matching between Ln-MOFs enables the epitaxial growth of heterojunctions, resulting in an increased number of color-coded blocks in spatial dimensions, thereby enhancing the encoding capacity. − However, the practical application of Ln-MOFs with static luminescent signals in confidential information protection is limited due to their direct readout nature. , …”

A Novel DNA Synthesis Platform Design with High-Throughput Paralleled Addressability and High-Density Static Droplet Confinement

“…Under the current paradigm of solid-state storage, the demand for storing massive data imposes enormous pressure on material resources, personnel allocation, industrial power, and land usage [2,3]. DNA, with its exceptionally high data density and ultra-long storage lifespan, is considered a highly promising alternative as the next-generation storage medium [4][5][6][7][8]. The process of utilizing DNA for data storage mainly involves four steps: data encoding, DNA synthesis, DNA sequencing, and data decoding.…”

Framework Nucleic Acids Combined with 3D Hybridization Chain Reaction Amplifiers for Monitoring Multiple Human Tear Cytokines

“…Recently, framework nucleic acids have enabled the fabrication of multidimensional ordered nanostructures with a variety of modifications for cancer diagnosis, drug delivery, biocomputing, and smart theranostics. [18][19][20][21][22][23][24][25][26] Additionally, HCR provides multiplexed, isothermal, enzyme-free amplification of molecular signals in diverse settings, and thus, it has been used for bioassays, in situ imaging, and the construction of DNA nanostructures. [27][28][29][30][31][32][33][34][35][36][37][38][39][40] However, their application in tear analysis remains a gap.…”