Dataset of potential Rhizoma Polygonati compound-druggable targets and partial pharmacokinetics for treatment of COVID-19

Mu, Chenglin; Sheng, Yifan; Wang, Qian; Amin, Amr; Li, Xugang; Xie, Yingqiu

doi:10.1016/j.dib.2020.106475

Cited by 7 publications

(10 citation statements)

References 7 publications

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“…Rhizoma polygonati (Huangjing, RP) is a ‘medicine food homology’ (MFH) known to be used in Traditional Chinese Medicine (TCM) for thousands of years with many natural products to maintain proper blood sugar levels, and exhibit many more pharmacological functions (Zhao et al, 2018 , 2021 ). Recently it has been shown that RP can also be used for the prevention of COVID-19 (Mu et al, 2020 , 2021 ). RP components include polysaccharides, alkaloids, lectins, saponins (Zhao et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

Xie

Kazybay

et al. 2021

Drug Delivery

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Section: Introductionmentioning

confidence: 99%

Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

Xie

Kazybay

et al. 2021

Drug Delivery

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“…In addition, studying the molecular network or signaling will be needed. Furthermore, investigating if these unique variants will have impacts on drug-gene interaction, signaling network, as well as impacts on pharmacokinetics using target chemical compounds that are used to treat COVID-19 patients, for example, Diosgenin, Syringaresinol-O-beta-D-glucoside, etc., are present in the traditional Chinese medicinal herb used to treat COVID-19 patients as an alternative could be a subject for future studies (57,58).We did analyze the number of mutations and sites of mutations of each of the crucial eleven mutant genes (Table 3). To avoid the biases of the sequence data, sequencing procedures including PCR-based sequencing and machines and analysis pipeline may cause errors we avoided genes that have been found mutated in < 10,000 global samples (supplementary table 2).…”

Section: )mentioning

confidence: 99%

A multi-population-based genomic analysis uncovers unique haplotype variants and crucial mutant genes in SARS-CoV-2

Sheikh

Huang²,

Parvin

et al. 2022

Preprint

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Background: COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. Rigorous detection and treatment strategies against SARS-CoV-2 have become very challenging due to continuous evolutions to the viral genome. Therefore, careful genomic analysis is sorely needed to understand transmission, the cellular mechanism of pathogenicity, and the development of vaccines or drugs. Objective: In this study, we intended to identify SARS-CoV-2 genome variants that may help understand the cellular and molecular foundation of coronavirus infections required to develop effective intervention strategies. Methods: SARS-CoV-2 genome sequences were downloaded from an open-source public database, processed, and analyzed for variants in target detection sites and genes. Results: We have identified six unique variants, G....AAC, T....AAC....T; AAC....T; C......C; C........C; and C........T at the nucleocapsid region and eleven major hotspot mutant genes: nsp3, surface glycoprotein, nucleocapsid phosphoprotein, ORF8, nsp6, nsp2, nsp4, helicase, membrane glycoprotein, 3'-5' exonuclease, and 2-O-ribose methyltransferases. In addition, we have identified eleven major mutant genes that may have a crucial role in SARS-CoV-2 pathogenesis. Conclusion: Studying haplotype variants and 11 major mutant genes to understand the mechanism of action of fatal pathogenicity and inter-individual variations in immune responses is inevitable for managing target patient groups with identified variants and developing effective anti-viral drugs and vaccines.

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“…Recently, we reported the computer-based analysis of the molecular docking of potential Rhizoma polygonati chemical compounds in combating COVID-19 and identified certain high-ranked compounds which may bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target proteins [ 92 - 93 ] . For example, (+)-syringaresinol-O-beta-D-glucoside potentially binds to the angiotensin-converting enzyme 2 (ACE2) of SARS-CoV-2, whereas diosgenin may bind to both ACE2 and RNA-dependent RNA polymerase based on calculation and computer modeling.…”

Section: Medicinal Values and Drug Development Of Mount Tai-rhizome ...mentioning

confidence: 99%

“…For example, (+)-syringaresinol-O-beta-D-glucoside potentially binds to the angiotensin-converting enzyme 2 (ACE2) of SARS-CoV-2, whereas diosgenin may bind to both ACE2 and RNA-dependent RNA polymerase based on calculation and computer modeling. All target genes of host cells are identified using computer modeling from the database [ 93 ] . Finally, in the future, relevant chemical compounds need to be identified to extract necessary drug-development chemicals.…”

Section: Medicinal Values and Drug Development Of Mount Tai-rhizome ...mentioning

confidence: 99%

Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

Nurtay

Sun

et al. 2021

Acupuncture and Herbal Medicine

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Recently, traditional Chinese medicine-based treatment has succeeded in fighting coronavirus disease 2019 (COVID-19), and Rhizoma polygonati (Huangjing) has been one of the recommended components. Its processed products play antidiabetic, antiviral, antitumor, antioxidation, antifatigue, antiaging, and immune enhancement roles. The climate in Mount Tai is mild, and the dense forest is suitable for the growth of Rhizome polygonati, which has gradually evolved into a unique specie. Considering the important medicinal value and pleasant taste of Mount Tai -Rhizoma polygonati, various healthy and functional food products, controlled by quality markers with anti-COVID-19 potential, as well as emergency foods can be developed. The study aimed to review current evidence on the nutritional value of Rhizoma polygonati from Mount Tai and its usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and food shortage. Most recent findings regarding herbal nanomedicine have revealed that nanoscale chemical compounds are potentially efficient in drug delivery or nanozyme catalysis upon bioprocessing. Nanoflower structure is found in processed Rhizoma polygonati by self-assembly and has wide application in enzymatic events, particularly nanoscale herbzyme. The novel findings regarding Mount Tai-Rhizoma polygonati could enhance its novel applications in chronic and hidden hunger, clinical nanomedicine, and as an anti-COVID-19 agent.

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Dataset of potential Rhizoma Polygonati compound-druggable targets and partial pharmacokinetics for treatment of COVID-19

Cited by 7 publications

References 7 publications

Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

A multi-population-based genomic analysis uncovers unique haplotype variants and crucial mutant genes in SARS-CoV-2

Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

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