Dataset on the epidemiology and genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico

Abstract

Dengue virus (DENV) evolution has had a significant impact on disease pathogenesis, virulence, and epidemiology in Mexico. Novel genotypic variation in DENV serotypes and genotypes may influence the magnitude and severity of dengue epidemics, as evidenced by 2009 data from Veracruz State. The data presented herein is related to the publication entitled “Epidemiological Implications of the Genetic Diversification of Dengue Virus (DENV) Serotypes and Genotypes in Mexico” [1]. Raw data and trees provide epidemiological data on DENV prevalence and a comprehensive phylogeny of both representative sequences collected from an NCBI repository, and 28 additional isolates from acute-phase plasma samples diagnosed with dengue fever or severe dengue (Raw sequencing data is hosted in the public repository Mendeley Data ( http://dx.doi.org/10.17632/bf2kdhhf6x.2 ). Phylogenetic trees for each DENV serotype (DENV-1, -2, -3 and -4) were constructed using these sequences by a maximum likelihood methodology as well as a Bayesian Markov chain Monte Carlo (MCMC) integration approach. Phylogenetic trees exhibited: (1) DENV-1, genotype V, (2) the DENV-2 Asian/American and Asian II genotypes, (3) DENV-3, genotype III, and (4) DENV-4, genotype I. This data can be beneficial for future analyses on DENV serotype and genotype structure and the introduction of novel DENV genotype sequences in the Americas, for the further elucidation of dengue etiology.

Short communications of a new circulating Dengue genotype III American II lineage in Mexico: outbreak 2022-2023

“…A phylogenetic analysis was performed, showed a grouping of the set with genotype III (Fig. 1) which has been in circulation for the last few years and since the first outbreak by DENV-3 in 1996(Domínguez-de-la-Cruz et al, 2020. using a subset by (Fonseca et al, 2019).…”

“…Major dengue (DENV) outbreaks have been identified in Mexico since the introduction of virus to the present, the serotypes can be divided in four (DENV-1; DENV-2; DENV-3; DENV-4) and various genotypes has been recorded (Domínguez-de-la-Cruz et al, 2020; Hernández-García et al, 2020). In 2022 and 2023 increase in cases of DENV has registered, 3,111 cases of DENV-1; 6,242 cases of DENV-2; 8,250 cases of DENV-3 and 348 cases of DNV-4 (Epidemiol, 2023); as a consequence of this increase in DENV cases an analysis of the genomic diversity of circulating viruses was carried out during this period and the genotypic diversity of each of the circulating serotypes was determined.…”