Datasets for the reporting of neoplasia of the testis: recommendations from the International Collaboration on Cancer Reporting

Abstract

We here describe the development of an evidence‐based cancer dataset by an International Collaboration on Cancer Reporting expert panel for the reporting of primary testicular neoplasia, and present the ‘required’ and ‘recommended’ elements to be included in the pathology report, as well as a commentary. This dataset encompasses the updated 2016 World Health Organisation classification of urological tumours, the results of an International Society of Urological Pathology consultation, and also staging with our preferred method: the American Joint Committee on Cancer version 8. Implementation of this dataset will facilitate consistent and accurate data collection between different cohorts, facilitate research, and hopefully result in improved patient management.

Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

“…Microscopic slides from the orchiectomy specimens and information from the original pathology reports will be reviewed by the same pathologist (TW) without knowledge of the clinical outcome. The most recent recommendations from the International Society of Urological Pathologists (ISUP)41 and the International Collaboration on Cancer Reporting (ICCR)42 regarding the reporting of microscopic features in testicular germ cell tumours with clear definitions of various parameters will be used. The following gross and microscopic parameters will be recorded, as defined in table 2: tumour size, tumour necrosis, LVI and tumour involvement of tunica albuginea, tunica vaginalis, rete testis, hilar soft tissue, epididymis and spermatic cord.…”

“…After completing the revision, the pathological features will be tested with regard to clinical outcome (see the ‘Statistical analysis’ section). National guidelines on handling and sampling of orchiectomy specimens have been standardised in Denmark for many years,45 and is in accordance with international recommendations 42. As such, adequate sampling and thereby a minimum of missing values is expected.…”

CD34 positive tubular basement membrane in testicular germ cell tumours: a potential staging pitfall

“…Sir : Staging of testicular germ cell tumours is essential for treatment planning and prognosis 1 . Lymphovascular invasion (LVI) is one key parameter that establishes pT2 in pathological staging and prognostic stage group IB for both seminoma and mixed germ cell tumours otherwise limited to the testis 1 . While current practice guidelines 2 consider surveillance preferred for stage I pure seminomas given the high rate of cure by orchiectomy alone, single‐agent carboplatin or radiotherapy remain considerations.…”

“…For mixed germ cell tumours, LVI is considered a risk factor, raising consideration of retroperitoneal lymph node dissection or multi‐agent adjuvant chemotherapy 2 . Thus, LVI assessment and reporting has been emphasised, including the consideration of immunohistochemical (IHC) markers as adjuncts 1 …”

“…Sir : Staging of testicular germ cell tumours is essential for treatment planning and prognosis 1 . Lymphovascular invasion (LVI) is one key parameter that establishes pT2 in pathological staging and prognostic stage group IB for both seminoma and mixed germ cell tumours otherwise limited to the testis 1 .…”