Date syrup–derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells

Taleb, Hajer; Morris, Roger H. K.; Withycombe, Cathryn; Maddocks, Sarah; Kanekanian, Ara

doi:10.1016/j.nutres.2016.02.010

Cited by 25 publications

(14 citation statements)

References 42 publications

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“…Our results are consistent with previously reported findings that polyphenols possess potent antioxidative and anti-inflammatory properties that contribute to the beneficial effects on heart health (Mechchate et al, 2021;Taleb et al, 2016) and indicated that the inhibitory effect on dyslipidemia in the HAF group was better.…”

Section: Discussionsupporting

confidence: 93%

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Zhou

Tian

et al. 2021

J Food Biochem

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Areca nut and Fuzhuan brick tea, a type of natural plant products, have obvious effects of fat reduction and weight loss; however, there is no report on their synergistic effect. This study investigated the effects of Fuzhuan brick tea supplemented with different concentrations of areca nut (5% (LAF), 10% (MAF), and 20% (HAF)) on serum and gut microbiota in Kunming (KM) mice. The results showed that Fuzhuan brick tea supplemented with areca nuts (AFTs) could reduce weight, prevent the accumulation of fat, inhibit the increase in the levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, blood glucose, free fatty acid, insulin, and total bile acid, alleviate the decrease in high-density lipoprotein cholesterol level, and regulate the composition of gut microbiota by high-fat diet intervention. The HAF group with 20% areca nut content showed the best effect. These results could provide a novel approach to prevent obesity and hyperlipidemia. Practical applicationsConsumption of areca nut and tea is widespread in Asia and other regions. As a controversial raw material, the damage due to areca nut to oral mucosa health has often

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Section: Discussionsupporting

confidence: 93%

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Zhou

Tian

et al. 2021

J Food Biochem

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“…Findings from our study support previous reports demonstrating that polyphenols can regulate COX-2 expression and secretion [35, 36]. In this study, we observed that Provinols did not affect the expression of the constitutive COX-1 isoform in both the aorta and SMA; paradoxically, however, Provinols reduced COX-2 expression in the aorta and enhanced its protein expression in SMA.…”

Section: Discussionsupporting

confidence: 90%

Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)

Agouni

Mostefai

et al. 2017

Oxidative Medicine and Cellular Longevity

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The aim of this work was to study the vascular effects of dietary supplementation of a nonalcoholic red wine polyphenol extract, Provinols, in Zucker fatty (ZF) obese rats. ZF or lean rats received diet supplemented or not with Provinols for 8 weeks. Vasoconstriction in response to phenylephrine (Phe) was then assessed in small mesenteric arteries (SMA) and the aorta with emphasis on the contribution of cyclooxygenases (COX). Although no difference in vasoconstriction was observed between ZF and lean rats both in SMA and the aorta, Provinols affected the contribution of COX-derived vasoconstrictor agents. The nonselective COX inhibitor, indomethacin, reduced vasoconstriction in vessels from both groups; however, lower efficacy was observed in Provinols-treated rats. This was associated with a reduction in thromboxane-A2 and 8-isoprostane release. The selective COX-2 inhibitor, NS398, reduced to the same extent vasoconstriction in aortas from ZF and Provinols-treated ZF rats. However, NS398 reduced response to Phe only in SMA from ZF rats. This was associated with a reduction in 8-isoprostane and prostaglandin-E release. Paradoxically, Provinols decreased COX-2 expression in the aorta, while it increased its expression in SMA. We provide here evidence of a subtle and paradoxical regulation of COX pathway by Provinols vessels from obese rats to maintain vascular tone within a physiological range.

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“…Interestingly, date syrup shows no cytotoxicity effect. Moreover, the polyphenolic compounds of date syrup were found to significantly reduce the expression of COX-2 and VEGF induced by tumor necrosis factor-alpha at both protein level and gene expression in comparison to untreated cells (Taleb et al, 2016). Most recently a study by Khan et al reported the effects of date, Ajwa variety, on cancer therapy; therefore date fruits might be used as useful as an adjunct therapy with conventional chemotherapeutics to achieve a synergistic effect against breast cancer (Khan et al, 2016).…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

et al. 2017

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Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3′-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects. Date palm fruits possess high nutritional and therapeutic value with significant antioxidant, antibacterial, antifungal, and anti-proliferative properties. This review focuses on the date fruit extracts and their benefits in individual health promoting conditions and highlights their applications as useful to the pharmaceutical and nutraceutical industries in the development of natural compound-based industrial products.

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Date syrup–derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells

Cited by 25 publications

References 42 publications

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Paradoxical Effect of Nonalcoholic Red Wine Polyphenol Extract, Provinols™, in the Regulation of Cyclooxygenases in Vessels from Zucker Fatty Rats (fa/fa)

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options

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