Technological innovation greatly supported global healthcare service in the recent coronavirus pandemic. The healthcare technical support came in two forms: (1) digitization of business functions and (2) development of new healthcare products. Healthcare-related data collection, preservation, and analysis using digital technologies support pandemic mitigation strategies. Gathering big data using the internet of things (IoT) technology, data analysis with the help of artificial intelligence (AI) techniques, mobile networking technologies for providing communication channels, and deploying the secure infrastructure are essential for the regular functioning of global healthcare services. In addition, healthcare operational data and infrastructure are highly vulnerable to traditional privacy and security-related issues. In addition, this chapter presents a survey of how security, trust, and privacy issues can deal with blockchain-based IoT computing architecture for securing healthcare information systems using lightweight cryptography.