Daudi Cell Specificity Correlates With the Use of a Vγ9-Vδ2 Encoded TCRγδ

Sturm, Els; Braakman, E.; Fisch, Paul; Sondel, Paul M.; Bolhuis, R. L. H.

doi:10.1007/978-3-642-76492-9_25

Cited by 1 publication

(1 citation statement)

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“…As mentioned previously, Daudi cells lack MHC Class I expression on their surface and are highly susceptible to γ δ T cell lysis [117, 118]. Cytotoxicity is significantly reduced though not abolished, when Daudi cells are engineered to express MHC [106], indicating that inhibitory NK or KIR receptors negatively regulate γ δ T cell function.…”

Section: γ δ Recognition Of Tumor Cellsmentioning

confidence: 99%

Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells

Urban

Chapoval

Pauza

2010

Journal of Immunology Research

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T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the α β TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate γ δ TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens. We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on γ δ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells. A unique mechanism for MHC-independent repertoire selection is linked to the control of effector function that is vital to the role for γ δ T cells in tumor surveillance. Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy.

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Section: γ δ Recognition Of Tumor Cellsmentioning

confidence: 99%