Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo

Zhou, Yi; Wang, Ruju; Chen, Bing; Shen, Dan; Hu, Yong; Xu, Peipei

doi:10.2147/ijn.s115037

Cited by 19 publications

(8 citation statements)

References 31 publications

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“…Our study revealed that PEG-CdTe nanoparticles could load DOX with high DL and EE (Fig. 2e ), which are consistent with other studies [ 12 , 13 ]. Moreover, the PEG-CdTe nanoparticles in diameter of 8.2 nm (< 10 nm) could be quickly metabolized by the urinary system [ 23 ], and PEG-CdTe-DOX nanoparticles in size of 78.31 nm (< 200 nm) prolonged the blood circulation time and reduced or even avoided plasma opsonization and absorption in the reticuloendothelial system [ 23 ].…”

Section: Discussionsupporting

confidence: 93%

“…PEG-CdTe QDs are efficiently internalized by cells through the fluid phase endocytosis and the lipid bilayer affinity on the plasma membrane surface [ 18 ]. As a drug nanoparticles vehicle, drugs loaded CdTe QDs can release drugs in a pH-controlled and pH-triggered pattern, and these nanoparticle complexes can release drugs at low pH that is similar to the tumor microenvironment [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Doxorubicin-Loaded PEG-CdTe Quantum Dots as a Smart Drug Delivery System for Extramedullary Multiple Myeloma Treatment

Chen

Yao

2018

Nanoscale Res Lett

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New drug treatments still do not improve the prognosis of extramedullary multiple myeloma (EMM) patients. Luckily, high-dose chemotherapy can raise the prognosis, but is intolerant to most patients because of drug cytotoxicity. Nanoparticles (NPs) are used as drug carriers to prolong drug circulation time, control drug release, reduce drug toxicity and bioavailability, and target specific sites. In this work, doxorubicin (DOX) was loaded in polyethylene glycol-modified cadmium telluride quantum dots (PEG-CdTe QDs). PEG-CdTe-DOX facilitated intracellular drug accumulation through polyethylene organizational compatibility and released DOX into the microenvironment in a pH-controlled manner, which enhanced the therapeutic efficacy and the apoptosis rate of myeloma cells (PRMI8226). PEG-CdTe-DOX improved the anti-tumor activity of DOX by regulating the protein expressions of apoptosis-associated genes. In summary, PEG-CdTe-DOX provides a specific and effective clinical treatment for EMM patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Loaded PEG-CdTe Quantum Dots as a Smart Drug Delivery System for Extramedullary Multiple Myeloma Treatment

Chen

Yao

2018

Nanoscale Res Lett

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“…In addition, it is used in the clinic to treat leukemia and lymphoma, which are at the origin of some cell lines that we have used in our study. Finally, like other anthracyclines, it is exported from cells by a broad range of transporters [ 34 ]. We used OCI-AML3 cells treated for one week with 1 mM and 5mM DCA or growing in OXPHOS medium.…”

Section: Resultsmentioning

confidence: 99%

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

et al. 2017

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Changes in metabolism require the efflux and influx of a diverse variety of metabolites. The ABC superfamily of transporters regulates the exchange of hundreds of substrates through the impermeable cell membrane. We show here that a metabolic switch to oxidative phosphorylation (OXPHOS), either by treating cells with dichloroacetate (DCA) or by changing the available substrates, reduced expression of ABCB1, ABCC1, ABCC5 and ABCG2 in wild-type p53-expressing cells. This metabolic change reduced histone changes associated to active promoters. Notably, DCA also inhibited expression of these genes in two animal models in vivo. In contrast, OXPHOS increased the expression of the same transporters in mutated (mut) or null p53-expressing cells. ABC transporters control the export of drugs from cancer cells and render tumors resistant to chemotherapy, playing an important role in multiple drug resistance (MDR). Wtp53 cells forced to perform OXPHOS showed impaired drug clearance. In contrast mutp53 cells increased drug clearance when performing OXPHOS. ABC transporter promoters contain binding sites for the transcription factors MEF2, NRF1 and NRF2 that are targets of the MAPK ERK5. OXPHOS induced expression of the MAPK ERK5. Decreasing ERK5 levels in wtp53 cells increased ABC expression whereas it inhibited expression in mutp53 cells. Our results showed that the ERK5/MEF2 pathway controlled ABC expression depending on p53 status.

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“… 121 Moreover, Zhou et al synthesized cysteamine-modified cadmium tellurium (Cys-CdTe) quantum dots to load daunorubicin (DNR) and GA to reduce the side effects and multidrug resistance (MDR) generated from DNR chemotherapy of malignant lymphoma, which could down-regulate the expression of P-glycoprotein on Raji/DNR cells resulting in minimizing MDR. 134 It was reported that GA and DTX could simultaneously release from PLGA nanoparticles, showing the synergistic antitumor effect attributed to the reversion of multidrug resistance of MCF-7/ADR cells to DTX and inducing cell apoptosis through downregulating the expression of P-gp. 126 …”

Section: Combination Therapymentioning

confidence: 99%

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Liu

Chen

Lin

et al. 2020

IJN

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Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo

Cited by 19 publications

References 31 publications

Doxorubicin-Loaded PEG-CdTe Quantum Dots as a Smart Drug Delivery System for Extramedullary Multiple Myeloma Treatment

Doxorubicin-Loaded PEG-CdTe Quantum Dots as a Smart Drug Delivery System for Extramedullary Multiple Myeloma Treatment

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

Gambogic Acid as a Candidate for Cancer Therapy: A Review

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