DAVID APPLE AND MILTON BONIUK, EDITORS Transscleral Choroidal Biopsy in the Diagnosis of Choroidal Lymphoma

Günduz, Kaan; Shields, Jerry A.; Shields, Carol L.; Eagle, Ralph C.; Diniz, Waltenio; Mercado, Gary; Chang, Wenguang

doi:10.1016/s0039-6257(99)00041-7

Cited by 27 publications

(5 citation statements)

References 23 publications

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“…Intraocular lymphoma secondary to disseminated, systemic disease is usually confined to the choroid (Table 1). 47–49 Although secondary lymphomatous ocular disease with predominant involvement of the retina and without uveal infiltration has been reported, this is exceptional 50,51 . Rarely, systemic lymphoma can present with anterior segment disease such as pseudohypopyon or iris infiltration 38,52,53 .…”

Section: Uveal Lymphomasmentioning

confidence: 99%

Understanding intraocular lymphomas

Coupland

Damato

2008

Clinical Exper Ophthalmology

279

263

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The purpose of this review is to describe the clinical features, pathology and molecular biology of intraocular lymphomas, which represent a heterogenous group of malignant neoplasms; to propose an anatomical classification of these tumours according to whether they occur in the retina or uvea; and to overview laboratory investigations and highlight factors required for successful biopsy. Recent findings show that retinal lymphomas are high-grade (i.e. aggressive), B-cell malignancies and are associated with a poor prognosis, with most patients dying of central nervous system disease. Immunophenotyping and somatic mutation analyses indicate that these lymphomas are probably derived from early post-germinal centre cells. Primary choroidal lymphomas are typically low-grade (i.e. indolent), B-cell tumours with morphological, immunophenotypical and genotypic features similar to extranodal marginal zone B-cell lymphomas (EMZL) elsewhere in the body. The putative cell of origin is the post-germinal centre (memory) B cell. Primary iridal lymphomas are very rare, with an equal distribution of B- and T-cell types and with a variable clinical course, most patients succumbing to their disease as a result of systemic dissemination. Primary lymphomas limited to the ciliary body are exceptionally rare. Secondary uveal lymphomas/leukaemias occur in patients with advanced systemic lymphoma or leukaemia, respectively. In summary, the term 'primary intraocular lymphoma (PIOL)' is imprecise. It would be preferable to refer to the various forms of intraocular lymphoma according to whether they are retinal, choroidal, ciliary or iridal and whether they are primary or secondary in these locations.

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Section: Uveal Lymphomasmentioning

confidence: 99%

Understanding intraocular lymphomas

Coupland

Damato

2008

Clinical Exper Ophthalmology

279

263

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“…However, it is difficult to obtain a tissue sample. In some inconclusive or late-stage cases, it may be necessary to perform enucleation for the definitive diagnosis [ 13 , 30 ]. In the present case, absence of any evidence of systemic disease at presentation and during 2 years of follow-up, could have facilitated the diagnosis of primary EMZL of the uvea.…”

Section: Discussionmentioning

confidence: 99%

Primary extranodal marginal zone B-cell lymphoma with diffuse uveal involvement and focal infiltration of the trabecular meshwork: a case report and review of literature

Gao

You

et al. 2015

BMC Ophthalmol

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BackgroundPrimary extranodal marginal zone lymphoma (EMZL) of the uvea is a rare condition and diagnosis may be challenging. We aim to report the clinical, histopathologic and immunohistochemical findings in a case of primary EMZL with diffuse uveal involvement and focal infiltration of the trabecular meshwork.Case presentationA 38-year-old male presented with 2-year progressive vision loss in the right eye. Fundus examination showed choroidal thickening with diffuse retinal pigment epithelium (RPE) changes and inferior exudative retinal detachment. Ultrasonography revealed low-reflective masses with diffuse thickening of the choroid involving the optic nerve and orbit. Despite treatment with steroids, his symptoms progressed over time. One year later, visual acuity of the right eye markedly decreased to no light perception and enucleation was performed. Histopathological findings revealed infiltrates of malignant cells in the choroid, iris, ciliary body and trabecular meshwork. Immunohistochemistry confirmed the diagnosis of primary uveal EMZL.ConclusionsThis is the first case reporting primary EMZL diffusely involving the uvea with focal infiltration of the trabecular meshwork.

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“…The analysis of CR samples is of paramount importance in the diagnosis/exclusion of malignancy, particularly in lymphoma [60,75,81,119,121,132,133,134,135,136]. Primary vitreoretinal lymphoma (PVRL) is the most common intraocular lymphoma [137]; usually, a high-grade diffuse large B-cell malignancy manifests with choroidal infiltration, vitritis, or even necrotizing retinitis are unresponsive to anti-viral, anti-bacterial, and anti-parasitic therapy.…”

Section: Chorioretinal Biopsymentioning

confidence: 99%

Intraocular Biopsy and ImmunoMolecular Pathology for “Unmasking” Intraocular Inflammatory Diseases

Mastropasqua

Carlo

Sorrentino

et al. 2019

JCM

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Intraocular inflammation can hide a variety of eye pathologies. In 33% of cases, to obtain a correct diagnosis, investigation of the intraocular sample is necessary. The combined analyses of the intraocular biopsy, using immuno-pathology and molecular biology, point to resolve the diagnostic dilemmas in those cases where history, clinical tests, and ophthalmic and systemic examinations are inconclusive. In such situations, the teamwork between the ophthalmologist and the molecular pathologist is critically important to discriminate between autoimmune diseases, infections, and intraocular tumors, including lymphoma and metastases, especially in those clinical settings known as masquerade syndromes. This comprehensive review focuses on the diagnostic use of intraocular biopsy and highlights its potential to enhance research in the field. It describes the different surgical techniques of obtaining the biopsy, risks, and complication rates. The review is organized according to the anatomical site of the sample: I. anterior chamber containing aqueous humor, II. iris and ciliary body, III. vitreous, and IV. choroid and retina. We have excluded the literature concerning biopsy for choroidal melanoma and retinoblastoma, as this is a specialized area more relevant to ocular oncology.

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DAVID APPLE AND MILTON BONIUK, EDITORS Transscleral Choroidal Biopsy in the Diagnosis of Choroidal Lymphoma

Cited by 27 publications

References 23 publications

Understanding intraocular lymphomas

Understanding intraocular lymphomas

Primary extranodal marginal zone B-cell lymphoma with diffuse uveal involvement and focal infiltration of the trabecular meshwork: a case report and review of literature

Intraocular Biopsy and ImmunoMolecular Pathology for “Unmasking” Intraocular Inflammatory Diseases

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