Day time-restricted feeding shows differential synchronizing effects on age-related changes of serotonin metabolism in SCN and the pineal gland in male Wistar rats

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

“…Food as an important non-photic zeitgeber (ZT) helps in the synchronization of the circadian and biological clock rhythms which are significantly impacted by any shift in the timing of dietary intake. Reddy et al (2022) provide pre-clinical evidence that TRE regimen as a non-photic stimulus was effective to prevent age-related changes in the levels of serotonin and its related metabolites in the suprachiasmatic nuclei (SCN) and pineal gland of male Wistar rats and helped to restore synchronization of biological rhythms. The age-associated alterations in the neural and temporal organization of the principal biological pacemaker located in the SCN of the anterior hypothalamus results in circadian dysfunction (Jagota et al 2021) and adversely impacts several physiological functions and behavioral processes.…”