Daylight photodynamic therapy: where and when is it possible?

Legat, Franz J.; Wolf, Peter

doi:10.1111/bjd.15541

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…2,8 This type of PDT uses the same prodrugs, but the light sources to induce the photodynamic reaction are different; instead of using a red-light source, such as in conventional PDT, daylight PDT uses natural sunlight. 9 This difference, combined with minimal incubation time, makes daylight PDT a procedure with little to no discomfort for the patient. Moreover, no equipment is needed and time spent in the hospital is minimized, thus making this variant a particularly interesting alternative.…”

Section: Introductionmentioning

confidence: 99%

“…Daylight PDT is a variant of PDT which has been increasingly used in the past few years 2,8 . This type of PDT uses the same prodrugs, but the light sources to induce the photodynamic reaction are different; instead of using a red‐light source, such as in conventional PDT, daylight PDT uses natural sunlight 9 . This difference, combined with minimal incubation time, makes daylight PDT a procedure with little to no discomfort for the patient.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy in dermatology: Beyond current indications

Queirós

Garrido

Silva

et al. 2020

Dermatologic Therapy

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Photodynamic therapy (PDT) has long been used in dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ, and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years, PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. These results, probably explained by its immunomodulatory, anti-inflammatory, and bactericidal effects, may lead to an expansion of PDT indications in the upcoming years. In this article, conditions where PDT may be useful are reviewed, thus highlighting the potential of this therapeutic modality for the dermatologist.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy in dermatology: Beyond current indications

Queirós

Garrido

Silva

et al. 2020

Dermatologic Therapy

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show abstract

“…Usually, red or blue wavelengths are required for dPDT in daylight. As the time required to penetrate the skin is much longer during the cPDT process, the applied photosensitizers are mainly located in deep tissue where cutaneous nerves are found, which causes moderate to severe pain [29]. It seems that dPDT results in patient satisfaction because of the almost zero pain as well as excellent cosmetic results upon treatment [30,31].…”

Section: Erdr1 and Photodynamic Therapymentioning

confidence: 99%

The Role of Erythroid Differentiation Regulator 1 (ERDR1) in the Control of Proliferation and Photodynamic Therapy (PDT) Response

Park¹,

Kim

Park

et al. 2020

IJMS

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Erythroid differentiation regulator 1 (ERDR1) was newly identified as a secreted protein that plays an essential role in maintaining cell growth homeostasis. ERDR1 enhances apoptosis at high cell densities, leading to the inhibition of cell survival. Exogenous ERDR1 treatment decreases cancer cell proliferation and tumor growth as a result of increased apoptosis via the regulation of apoptosis-related gene expression. Moreover, ERDR1 plays a pivotal role in skin diseases; ERDR1 expression in actinic keratosis (AK) is negatively correlated with the increase in apoptosis. Because of its high specificity and efficiency, photodynamic therapy (PDT) is a common therapy for patients with various skin diseases, including cancer. Many studies indicate that apoptosis is mainly induced by PDT treatment. As an apoptosis inducer, the recovery of the ERDR1 expression after PDT is correlated with good therapeutic outcomes. Here, we review recent findings that highlight the function of ERDR1 in the control of apoptosis. Thus, ERDR1 may have a role in the apoptosis regulation of target cells in the lesions, as the recovery of its expression after PDT is correlated with good therapeutic outcomes.

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Daylight photodynamic therapy: where and when is it possible?

Abstract: Linked Article: O'Mahoney et al. Br J Dermatol 2017; 176:1607–1616.

Cited by 2 publications

References 7 publications

Photodynamic therapy in dermatology: Beyond current indications

Photodynamic therapy in dermatology: Beyond current indications

The Role of Erythroid Differentiation Regulator 1 (ERDR1) in the Control of Proliferation and Photodynamic Therapy (PDT) Response

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