Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition

Wu, Yuanhao; Chen, Qixian; Li, Qiaoying; Lu, Hongguang; Wu, Xinshi; Ma, Jianbiao; Gao, Hui

doi:10.1039/c6tb01629d

Cited by 26 publications

(19 citation statements)

References 30 publications

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“…For instance, Huang and co‐workers constructed an elegant host–guest inclusion complex from water‐soluble pillar[6]arene and a tetraphenylethene (TPE) derivative that exhibited strong fluorescence in dilute solution . Interestingly, fluorescent supramolecular assemblies that possess stimuli‐responsive properties and dynamic features have been fabricated from AIEgen‐containing building blocks, in particular with the aid of supramolecular macrocycles, such as crown ethers, calix[ n ]arenes, cyclodextrins, cucurbit[ n ]urils, and pillar[ n ]arenes, instead of simple addition of poor solvents to induce the formation of disorganized aggregates. However, research on the cooperative manipulation of AIE by a polymer host material that contains many synthetic macrocycles installed on one single polymer chain has rarely been proposed and reported .…”

Section: Characterization Of Copolymersmentioning

confidence: 99%

Efficient Aggregation‐Induced Emission Manipulated by Polymer Host Materials

et al. 2019

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luminogens with aggregation-induced emission (AIE) properties, referred to as AIEgens, first discovered by Tang and coworkers in 2001, exhibit enhanced emission in the aggregated state, [1] leading to the rapid development of AIE materials with diverse applications in ion detection, [2] explosive sensors, [3] cell imaging, [4] photodynamic therapy, [5] optoelectronic systems, [6] and light-harvesting systems. [7] A seminal approach to fabricate smart luminescent materials is the manipulation of AIEgens with supramolecular macrocycle-based host-guest chemistry, which could induce remarkable enhancement of fluorescence intensity of materials due to the host-guest interactions between macrocycles and AIEgens that restrict the intramolecular rotation of luminophores.[8] Pillar[n]arenes, as a new generation of synthetic macrocyclic hosts first reported by Ogoshi et al. in 2008, have proved captivating advantages including symmetrical and rigid structure, versatile functionality, [9] and good solubility. [10] Among the members of the pillar[n]arene family, pillar[5]arene and its derivatives, in which 1,4-disubstituted hydroquinones are connected by five methylene units in the 2,5-positions, exhibit the advantages of: 1) desirable host candidate to bind neutral molecules in organic solvents due to the electron-rich cavity; [11] 2) high yielding in the preparation process for further functionalization; [12] and 3) rigid structure donated stiff component in the fabrication of functional materials, and have showed great potential in sensors, [13] biomedical field, [14] catalysts, [15] separation and storage, [16] supramolecular gels, [17] and light-harvesting systems. [18] For instance, Huang and co-workers constructed an elegant host-guest inclusion complex from water-soluble pillar[6]arene and a tetraphenylethene (TPE) derivative that exhibited strong fluorescence in dilute solution. [19] Interestingly, fluorescent supramolecular assemblies that possess stimuli-responsive properties and dynamic features have been fabricated from AIEgen-containing building blocks, in particular with the aid of supramolecular macrocycles, such as crown ethers, [20] calix[n]arenes, [21] cyclodextrins, [22] cucurbit[n] urils, [23] and pillar[n]arenes, [21,24] instead of simple addition of poor solvents to induce the formation of disorganized aggregates. However, research on the cooperative manipulation of AIE by a polymer host material that contains many synthetic macrocycles installed on one single polymer chain has rarely Linear copolymer hosts bearing a number of pillar[5]arene dangling side chains are synthesized for the facile construction of highly emissive supramolecular polymer networks (SPNs) upon noncovalently cross-linking with a series of tetraphenyethylene (TPE)-based tetratopic guests terminated with different functional groups through supramolecular host-guest interactions. An extremely high fluorescence quantum yield (98.22%) of the SPNs materials is obtained in tetrahydrofuran (THF) by fine-tuning the parameters...

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Section: Characterization Of Copolymersmentioning

confidence: 99%

Efficient Aggregation‐Induced Emission Manipulated by Polymer Host Materials

et al. 2019

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“…As exhibiting different interaction manners with pathogen surfaces before and after assembly, supramolecular complexes are widely applied in discrimination and identification of pathogen with rapid and facile conveniences. In order to further endow the cationic polymer complexed supramolecular system with antimicrobial function, Gao's group developed an AIE-featured multifunctional host-guest system (PEI-CD-Arg-TPEDB)112. It composed AIEgen (4,4'-(1,2-diphenylethene-1,2-diyl) bis(1,4-phenylene)diboronic acid, TPEDB) that linked to cyclodextrin (CD) via host-guest interaction, and polyethyleneimine (PEI) which was covalently modified by arginine (Arg).…”

Section: Bacterial Detection and Killingmentioning

confidence: 99%

AIE-based theranostic systems for detection and killing of pathogens

He¹,

Xiong²,

Zhao³

et al. 2019

Theranostics

129

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Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection.

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“…Gao's group developed another novel multifunctional host‐guest AIE active system based on cationic Polyethyleneimine modified arginine‐ (4,4’‐(1,2‐diphenylethene‐1,2‐diyl) bis(1,4‐phenylene) diboronic acid, TPEDB) that linked to cyclodextrin, PEI‐CD‐Arg‐TPEDB) for bacterial detection and elimination . The incorporation of Arginine extensively reduces bacterial activity via electrostatic attraction with the anionic bacterial surface and disruption of Ca 2+ salt bridges which is crucial for plaque adhesion of bacteria.…”

Section: Aie Active Polymer For Dectection and Elimination Of Bacteriamentioning

confidence: 99%

AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

et al. 2020

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The infections caused by bacteria have affected human health severely. The bacterial infections spread either directly or indirectly by coming in contact with the food during packaging or by the use of medical devices. The efficient theranostic systems for bacteria provide therapeutic effects that have received attentions in the research field. In this prospect, the fluorescent materials have gained tremendous recognition in the biological applications due to their excellent species diversity, optical properties and high sensitivity. However, most of the conventional fluorophores suffer aggregation‐caused quenching (ACQ) effects in the aggregated state. The opposite of ACQ is Aggregation Induced Emission (AIE), where AIEgens play an important role in the imaging, detecting and killing the bacteria as well. In this context, we have summarized the applications of AIEgens on multiple bacterial imaging, detection, discrimination and antibacterial activity to understand the modern theranostic system.

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Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition

Abstract: Light-stimulated AIE-based nanocomplexes have been developed as convenient tools to accomplish the tasks of the detection and inhibition of bacteria.

Cited by 26 publications

References 30 publications

Efficient Aggregation‐Induced Emission Manipulated by Polymer Host Materials

Efficient Aggregation‐Induced Emission Manipulated by Polymer Host Materials

AIE-based theranostic systems for detection and killing of pathogens

AIEgen‐Based Fluorescent Nanomaterials for Bacterial Detection and its Inhibition

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