Days of Antibiotic Spectrum Coverage Trends and Assessment in Patients with Bloodstream Infections: A Japanese University Hospital Pilot Study

Maeda, Masako; Nakata, Mari; Naito, Yohei; Yamaguchi, Kozue; Yamada, Kaho; Kinase, Ryoko; Teratani, Takuma; On, Rintaro; Tokimatsu, Issei

doi:10.3390/antibiotics11121745

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…On the other hand, DASC/DOT did not correlate with DOT. This study also suggests that the DASC/DOT can be employed as an independent indicator for evaluating the spectrum of antimicrobial agents used, as evidenced by previous studies 11 . However, a weak correlation was observed between AUSC/AUD and AUD, suggesting that AUSC/AUD was influenced by variations in DDD.…”

Section: Discussionsupporting

confidence: 76%

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Evaluation of antimicrobial stewardship activities using antibiotic spectrum coverage

Tanuma,

Sakurai,

Nakaminami

et al. 2024

Sci Rep

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Recently, the days of antibiotic spectrum coverage (DASC) using the antibiotic spectrum coverage (ASC) score was reported as a new tool for measuring antimicrobial use. The days of therapy (DOT) are required to calculate the DASC, making it impossible to use when patient-level information is unavailable. Therefore, we have defined a new measure of antimicrobial use for antimicrobial spectrum coverage (AUSC) using antimicrobial use density (AUD) and ASC scores. In this study, we have investigated the use of antimicrobial agents retrospectively examined for monthly prescriptions between 2016 and 2022, and whether the AUSC could be used as a new measure. Our data showed that the AUD, AUSC, DOT, and DASC increased, whereas AUSC/AUD and DASC/DOT decreased over the study period. In addition, no correlation was found between DOT and DASC/DOT (ρ = − 0.093, p = 0.399), whereas there was a weak correlation between AUD and AUSC/AUD (ρ = − 0.295, p = 0.006). Therefore, in this study, the use of AUSC is considered less beneficial when DASC can be calculated based on DOT. On the other hand, in institutional settings where DOT cannot be calculated, AUSC may be useful as a new measure to evaluate antimicrobial use.

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Section: Discussionsupporting

confidence: 76%

“…Recently, the days of antibiotic spectrum coverage (DASC), which uses the antibiotic spectrum coverage (ASC) score, has been proposed as a new tool for evaluating antimicrobial use 10 , 11 . The DASC is calculated from the DOT and ASC scores, which combine consumption and spectrum.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial stewardship activities using antibiotic spectrum coverage

Tanuma,

Sakurai,

Nakaminami

et al. 2024

Sci Rep

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Trends in inpatient antimicrobial consumption using days of therapy and days of antibiotic spectrum coverage: A nationwide claims database study in Japan

Kanda,

Ohbe,

et al. 2024

Journal of Infection and Chemotherapy

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Antibiotic spectrum coverage scoring as a potential metric for evaluating the antimicrobial stewardship team activity: a single-center study

Oda,

Hayashi,

Yamamoto

et al. 2024

Infect. Control Hosp. Epidemiol.

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Objective: Days of antibiotic spectrum coverage (days of ASC: DASC) is a metric for antibiotic usage calculated by ASC scores for spectrum and addresses limitations of days of therapy (DOT), which does not include spectrum. This study aims to investigate whether ASC-related metrics offer different aspects compared to aggregated DOT for all antibiotics (DOTtotal) and to assess their correlation in evaluating the impact of antimicrobial stewardship team (AST) programs. Design: Retrospective. Setting: A single center within an 845-bed hospital. Methods: Trends in DOTtotal, DASC, and the DASC/DOT ratio, representing the average spectrum coverage per therapy day, were analyzed pre- and post-AST programs (April 2018) from January 2015 to December 2023, using interrupted time series analysis. Independent of the DASC/DOT, we also advocated ASC-stratified DOT (ASDOT), which facilitates comprehensive evaluation of DOT across ASC scores of <6, 6–10, and >10, representing narrow-, intermediate-, and broad-spectrum antibiotics. Results: Among inpatients, AST programs significantly moderated the increasing trends of these metrics. Specifically, although the rates of increase in DOTtotal and DASC were slowed or plateaued, the DASC/DOT ratio decreased (P < 0.001). ASDOT metrics revealed a decrease and subsequent plateau in DOTtotal for the broad- and intermediate-spectrum antibiotics, with an increase observed for the narrow-spectrum antibiotics (P < 0.001 for each). DASC did not provide additional insights in the outpatient’s population. Conclusions: The study demonstrates that ASC-related metrics may yield different and useful conclusions about the effectiveness of AST programs for inpatients.

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Days of Antibiotic Spectrum Coverage Trends and Assessment in Patients with Bloodstream Infections: A Japanese University Hospital Pilot Study

Cited by 3 publications

References 37 publications

Evaluation of antimicrobial stewardship activities using antibiotic spectrum coverage

Evaluation of antimicrobial stewardship activities using antibiotic spectrum coverage

Trends in inpatient antimicrobial consumption using days of therapy and days of antibiotic spectrum coverage: A nationwide claims database study in Japan

Antibiotic spectrum coverage scoring as a potential metric for evaluating the antimicrobial stewardship team activity: a single-center study

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