Daytime Sleepiness and Cognitive Impairment in the Elderly Population

Ohayon, Maurice M.; Vecchierini, Marie-Françoise

doi:10.1001/archinte.162.2.201

Cited by 273 publications

(218 citation statements)

References 44 publications

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“…In our study, short or long sleep was also found to be associated not only with cognitive impairment, but also depressive symptoms in elderly Japanese. Relationships of short sleep and sleep disorders with cognitive impairment have been reported (Fulda and Shulz, 2001;Ohayon and Vecchierini, 2002). Previous studies have also suggested its association with mental health problems, such as anxiety disorder and major depressive disorder (Ohayon, 2004).…”

Section: Discussionmentioning

confidence: 98%

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Lee

Shinkai

2005

Int J Geriat Psychiatry

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SUMMARYBackground Cognitive impairment and depressive symptoms impose a heavy burden on the care of the elderly in Japan and Korea, two of the fastest aging nations in Asia. The purpose of this study was to examine and compare factors associated with cognitive impairment and depressive symptoms among older persons in the two countries. Methods In 2002, representative samples of community-dwelling people aged 65 and older were selected among residents in Anyang, Korea and Yoita, Japan. Mini-Mental State Examination and Geriatric Depression Scale were used to assess the elderly's mental status. Sociodemographics, physical function, chronic conditions, social support, and health behaviors were examined to identify significant associations. Results The prevalence of cognitive impairment in older adults was 17.0% in Anyang and 14.6% in Yoita. The rates for depressive symptoms were 15.2% and 19.8%, respectively. Overall, functional capacity was the universal factor significantly associated with mental conditions. Self-rated health and social support were also found to be independently associated with depressive symptoms in the study subjects. Differences in the patterns of association by community, however, were notable for other characteristics. For example, in factors associated with cognitive impairment, sociodemographic factors such as age, gender, and education were significant among Koreans, whereas socio-behavioral factors such as obesity, social support and hospitalization experience were found to be significant for older Japanese residents. Conclusions Similarities in the patterns of association indicate the need for joint explorations into the role these factors play in affecting the mental health of older persons. Socioeconomic and regional differentials, however, may account for the disparity in the associations observed, suggesting the importance of developing mental health programs sensitive to the older individual's culture.

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Section: Discussionmentioning

confidence: 98%

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Lee

Shinkai

2005

Int J Geriat Psychiatry

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“…There is evidence in the literature that sleep disturbances can affect cognition in elderly people, especially attention and memory (Kunz and Herrmann, 2000;Ohyon and Vecchierini, 2002). In addition, elderly people with a mild cognitive impairment typically have difficulties with attention and memory demands (Tuokko and Frerichs, 2000;Hedden and Gabrieli, 2004).…”

Section: Performance and Mood Assessment Batterymentioning

confidence: 99%

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Mathias

Zihl

Steiger

et al. 2004

Neuropsychopharmacol

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Aging is associated with dramatic reductions in sleep continuity and sleep intensity. Since gaboxadol, a selective GABA A receptor agonist, has been demonstrated to improve sleep consolidation and promote deep sleep, it may be an effective hypnotic, particularly for elderly patients with insomnia. In the present study, we investigated the effects of subchronic gaboxadol administration on nocturnal sleep and its residual effects during the next days in elderly subjects. This was a randomized, double-blind, placebo-controlled, balanced crossover study in 10 healthy elderly subjects without sleep complaints. The subjects were administered either placebo or 15 mg gaboxadol hydrochloride at bedtime on three consecutive nights. Sleep was recorded during each night from 2300 to 0700 h and tests assessing attention (target detection, stroop test) and memory function (visual form recognition, immediate word recall, digit span) were applied at 0900, 1400, and 1700 h during the following days. Compared with placebo, gaboxadol significantly shortened subjective sleep onset latency and increased self-rated sleep intensity and quality. Polysomnographic recordings showed that it significantly decreased the number of awakenings, the amount of intermittent wakefulness, and stage 1, and increased slow wave sleep and stage 2. These effects were stable over the three nights. None of the subjects reported side effects. Next-day cognitive performance was not affected by gaboxadol. Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects.

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“…Our findings are in accordance with population based studies where short sleep duration was not associated, either by self-report 28 or actigraphy, 27 with MMSE. Short sleep duration can cause deficits in attention and vigilance through excessive sleepiness, 42 but the mechanisms by which long sleep duration could affect cognitive function are not fully understood.…”

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confidence: 99%

Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study

Ramos

Dong

Elkind

et al. 2013

Journal of Clinical Sleep Medicine

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Daytime Sleepiness and Cognitive Impairment in the Elderly Population

Abstract: Among elderly individuals in the general population, EDS is an important risk factor for cognitive impairment. A complaint of EDS by an elderly patient should signal the possibility of an underlying cognitive impairment in need of evaluation.

Cited by 273 publications

References 44 publications

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan

Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects

Association between Sleep Duration and the Mini-Mental Score: The Northern Manhattan Study

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