Daytime variations in glucose tolerance in people with impaired glucose tolerance

Santos, Marcio Lustosa; Aragon, Flávio Ferrari; Padovani, Carlos Roberto; Pimenta, W P

doi:10.1016/j.diabres.2006.04.007

Cited by 18 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…showed that insulin resistant subjects suffered from a loss of rhythm in insulin sensitivity, which was partially compensated by an enhancement of the rhythm in insulin levels26. Two other studies found increased 24 h profiles of glucose and C-peptide in IFG subjects33 and first-degree relatives of type 2 diabetic patients34, with conflicting results regarding 24 h insulin levels.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated FFA levels are important players in the development of insulin resistance51 and diurnal variation of FFA response have been shown to contribute to the decline in glucose tolerance as the day progresses29. However, some studies demonstrated no difference in daytime variations between NGT subjects and individuals with IGT3334 and therefore this question requires further research.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial

Keßler

Hornemann

Petzke

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Diurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients and its effects on glycaemic control after prolonged consumption are not studied in detail. In this cross-over trial, 29 non-obese men were randomized to two four-week diets: (1) carbohydrate-rich meals until 13.30 and fat-rich meals between 16.30 and 22.00 (HC/HF) versus (2) inverse sequence of meals (HF/HC). After each trial period two meal tolerance tests were performed, at 09.00 and 15.40, respectively, according to the previous intervention. On the HF/HC diet, whole-day glucose level was increased by 7.9% (p = 0.026) in subjects with impaired fasting glucose and/or impaired glucose tolerance (IFG/IGT, n = 11), and GLP-1 by 10.2% (p = 0.041) in normal glucose-tolerant subjects (NGT, n = 18). Diet effects on fasting GLP-1 (p = 0.009) and PYY (p = 0.034) levels were observed in IFG/IGT, but not in NGT. Afternoon decline of glucose tolerance was more pronounced in IFG/IGT and associated with a stronger decrease of postprandial GLP-1 and PYY levels, but not with changes of cortisol rhythm. In conclusion, the HF/HC diet shows an unfavourable effect on glycaemic control in IFG/IGT, but not in NGT subjects. Consequently, large, carbohydrate-rich dinners should be avoided, primarily by subjects with impaired glucose metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial

Keßler

Hornemann

Petzke

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has been observed previously that, in subjects with NGT, postprandial glucose levels after the evening meal are higher, but with similar insulin and proinsulin responses when compared with breakfast and lunch [20]. In the same study, in subjects with impaired glucose tolerance (IGT), in addition to increased glucose levels after dinner, the plasma glucose concentrations after breakfast were elevated with increased insulin and similar proinsulin responses relative to lunchtime [20]. Hence, there appears to be a shift in the diurnal variation in glucose homeostasis and pancreatic B‐cell function from normoglycaemia to impaired glucose tolerance.…”

Section: Discussionmentioning

confidence: 99%

Daytime variability of postprandial glucose tolerance and pancreatic B‐cell function using 12‐h profiles in persons with Type 2 diabetes

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Similarly in humans, a carbohydrate‐rich diet is favoured during breakfast and high‐fat diets are preferred during evening meals . Carbohydrates are metabolized better during breakfast because, also in relation to the glucostatic theory, the body metabolically responds more readily to a glucose stimulus, since the fasting glucose level then is relatively stable, and very clearly indicates the first transient glucose decline .…”

Section: Circadian Misalignment Endocrinology and Energy Homeostasismentioning

confidence: 99%

Chronobiology, endocrinology, and energy‐ and food‐reward homeostasis

2013

View full text Add to dashboard Cite

Energy- and food-reward homeostasis is the essential component for maintaining energy balance and its disruption may lead to metabolic disorders, including obesity and diabetes. Circadian alignment, quality sleep and sleep architecture in relation to energy- and food-reward homeostasis are crucial. A reduced sleep duration, quality sleep and rapid-eye movement sleep affect substrate oxidation, leptin and ghrelin concentrations, sleeping metabolic rate, appetite, food reward, hypothalamic-pituitary-adrenal (HPA)-axis activity, and gut-peptide concentrations, enhancing a positive energy balance. Circadian misalignment affects sleep architecture and the glucose-insulin metabolism, substrate oxidation, homeostasis model assessment of insulin resistance (HOMA-IR) index, leptin concentrations and HPA-axis activity. Mood disorders such as depression occur; reduced dopaminergic neuronal signaling shows decreased food reward. A good sleep hygiene, together with circadian alignment of food intake, a regular meal frequency, and attention for protein intake or diets, contributes in curing sleep abnormalities and overweight/obesity features by preventing overeating; normalizing substrate oxidation, stress, insulin and glucose metabolism including HOMA-IR index, and leptin, GLP-1 concentrations, lipid metabolism, appetite, energy expenditure and substrate oxidation; and normalizing food reward. Synchrony between circadian and metabolic processes including meal patterns plays an important role in the regulation of energy balance and body-weight control. Additive effects of circadian alignment including meal patterns, sleep restoration, and protein diets in the treatment of overweight and obesity are suggested.

show abstract

Daytime variations in glucose tolerance in people with impaired glucose tolerance

Cited by 18 publications

References 25 publications

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial

Daytime variability of postprandial glucose tolerance and pancreatic B‐cell function using 12‐h profiles in persons with Type 2 diabetes

Chronobiology, endocrinology, and energy‐ and food‐reward homeostasis

Contact Info

Product

Resources

About