In rock formations prone to karstification there are only limited geological/hydrological principles that allow a safe prognosis of the existence and location of karstic and fault structures. A combination of geophysical borehole radar measurements utilizing both reflection and crosshole probe setups can be used to reliably detect anomalous structures, especially air‐filled karstic cavities and fault zones, when a sensible measuring concept for karstified or crystalline rocks is applied. Besides the determination of the anomalous structure's location it is also possible to distinguish its type of filling. Using examples from the major railway project Albaufstieg between Wendlingen‐Ulm the investigation concepts ahead of the tunnel construction are presented. The borehole radar measurements were successfully utilized during different phases of the tunnel excavation and could be integrated into the construction process without significant delays, thus contributing to a safe construction process and later operation of the tunnels. The reliability and high efficiency of these borehole radar investigation concepts places this technology of karst detection at a significant advantage over the commonly applied seismic methods, especially in karst‐prone and crystalline rocks.