DBU-catalyzed 1,6-addition of quinazolinones and quinolones to para‑quinone methides

1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) Promoted N-Alkylation of Quinazolinones through Nucleophilic Substitution of Benzyl Alcohols

“…Although no metal was used in this protocol, stoichiometric byproduct triphenylphosphine oxide was produced, making this protocol less attractive. On the other hand, 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) has been widely applied in organic synthesis for its unique ability to stabilize ionic species. − In continuation of our interest in the synthesis of quinazolinone derivatives, we tried to find whether HFIP could promote the alkylation reaction of quinazolinones and alcohols in the absence of any metal catalysts.…”