DC-SIGN (CD209) Promoter -336 A/G Polymorphism Is Not Associated with Dengue Fever at Burkina Faso, West Africa

YOUGBARE, Fiffou; Tapsoba, Aziz Sidi Aristide; Sorgho, Pegdwendé Abel; BAYALA, Bagora; Traoré, L.; BADO, Prosper; BAZIE, Bapio Valérie Elvira Jean Télesphore; Zoure, Abdou Azaque; Traoré, Esther Mah Alima; Zohoncon, Théodora Mahoukèdè; Tovo, S; Yonli, Albert Théophane; Kiba, Alice; Djigma, Florencia Wendkuuni; Simporé, Jacques

doi:10.4236/jbm.2023.111017

JBM

2023

DOI: 10.4236/jbm.2023.111017

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DC-SIGN (CD209) Promoter -336 A/G Polymorphism Is Not Associated with Dengue Fever at Burkina Faso, West Africa

Fiffou YOUGBARE¹,

Aziz Sidi Aristide Tapsoba²,

Pegdwendé Abel Sorgho³

et al.

Abstract: Objective: The aim of this study was to characterize the polymorphisms of the DC-SIGN (−336 A/G, rs4804803) gene and their association with the immunopathogenicity of dengue fever in Burkina Faso. Methods: A total of three hundred forty-one subjects, patients of all ages have been included in the study: 208 persons presenting clinical signs of dengue fever which were confirmed by diagnostic and 133 Healthy Controls. Genotyping for the CD209 variant

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2024

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All-Atom Perspective of the DENV-3 Methyltransferase Inhibition Mechanism

Liu,

Pang,

et al. 2024

J. Phys. Chem. B

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The Dengue virus (DENV) is an enveloped, single-stranded RNA virus with several antigenically distinct serotypes (DENV-1 to DENV-5). Dengue fever, as a major public health threat transmitted by mosquitoes, affects millions of people worldwide (especially in tropical and subtropical regions). Toward drug developments of DENV, the nonstructural protein 5 methyltransferase (MTase) serves as an attractive target. The MTase transforms S-adenosyl methionine to S-adenosyl homocysteine (SAH), which is thereby selected as the target with which external drugs compete with. In this work, using alanine scanning with generalized Born and interaction entropy (ASGB-IE), we provide an all-atom perspective of the protein−ligand interactions formed by DENV-3 MTase and SAH derivatives. Residues with consistently high contributions to stabilization are summarized, and the general DENV-3 MTase inhibition mechanism is elucidated. Additionally, the mutational impact on binding thermodynamics is found to be entropy-driven. We also highlight the advantage of the ASGB-IE method for affinity estimation compared to standard end-point protocols, which is highly related to the selection of interfacial residues in free energy estimation. Finally, we performed a thorough scan of the mutational space on critical sites (saturation mutagenesis) and identified 14 mutants causing resistance to the current inhibitors.

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All-Atom Perspective of the DENV-3 Methyltransferase Inhibition Mechanism

Liu,

Pang,

et al. 2024

J. Phys. Chem. B

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show abstract

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DC-SIGN (CD209) Promoter -336 A/G Polymorphism Is Not Associated with Dengue Fever at Burkina Faso, West Africa

Cited by 1 publication

References 19 publications

All-Atom Perspective of the DENV-3 Methyltransferase Inhibition Mechanism

All-Atom Perspective of the DENV-3 Methyltransferase Inhibition Mechanism

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