DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia

Yang, Sean; Cho, Eun Hee; Choi, So Young; Lee, Yun Kyung; Park, Jae Hyun; Kim, Min Kyung; Park, Jin Yeon; Choi, Hyeong Jwa; Lee, Jeong Ik; Ko, Hyun Sook; Park, Seung Hwa; Hwang, Han Sung; Kang, Young Sun

doi:10.1016/j.jri.2017.09.012

Cited by 57 publications

(48 citation statements)

References 24 publications

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“…DC-SIGN positive HBCs were present in all 3 stages of pregnancy; albeit with varying degrees of DC-SIGN expression. Consistent with Yang et al ( 28 ) we found that DC-SIGN positive third trimester macaque HBCs co-expressed CD14, CD68, and CD163. In contrast to Bockle et al ( 29 ), we detected a large population of DC-SIGN positive HBC in third trimester placenta that co-expressed HLA-DR (23% in cluster 6).…”

Section: Hofbauer Cells In Normal Pregnancysupporting

confidence: 92%

“…Infarction, intervillous thrombosis, and abruption is more common in placentas from preeclampsia patients than patients with HELLP ( 55 ). Furthermore, HBC numbers, and their expression of DC-SIGN and IL-10 are significantly reduced in patients with severe preeclampsia ( 28 , 57 ). It has been suggested that the reduction of HBCs in preeclampsia may be promoting inflammatory damage due to the loss of tolerance-promoting HBCs ( 28 ).…”

Section: The Role Of Hbcs In Pregnancy Complicationsmentioning

confidence: 99%

“…Furthermore, HBC numbers, and their expression of DC-SIGN and IL-10 are significantly reduced in patients with severe preeclampsia ( 28 , 57 ). It has been suggested that the reduction of HBCs in preeclampsia may be promoting inflammatory damage due to the loss of tolerance-promoting HBCs ( 28 ). In contrast to preeclampsia, patients with HELLP exhibit increased numbers of CD68 + HBCs, and it was concluded that this may be due to increased inflammation or an adaptive response ( 56 ).…”

Section: The Role Of Hbcs In Pregnancy Complicationsmentioning

confidence: 99%

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Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

2018

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Hofbauer cells are placental villous macrophages of fetal origin that are present throughout pregnancy. Although Hofbauer cell populations are antigenically and morphologically heterogeneous, their epigenetic, antigenic, and functional profiles most closely resemble alternatively activated macrophages or what are referred to as M2a, M2b, M2c, and M2d polarity subtypes. Consistent with an M2-like profile, these cells play an important role in placental development including vasculogenesis and angiogenesis. During placental inflammation Hofbauer cells may produce pro-inflammatory cytokines or mediators that damage the villous cell barrier, and induce fibrotic responses within the villi as a continuum of chronic inflammation. However, to date, there is no evidence that Hofbauer cells become classically activated or adopt an M1 polarity phenotype that is able to kill microbes. To the contrary, their predominant M2 like qualities may be why these cells are ineffective in controlling most TORCH infections. Moreover, Hofbauer cells may contribute to vertical transmission of various pathogens to the fetus since they can harbor live virus and serve as reservoirs within the placenta. The goal of this review is to summarize what is currently known about the role of Hofbauer cells in normal and complicated pregnancies that involve immunologic disorders, inflammation, and/or infection.

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Section: Hofbauer Cells In Normal Pregnancysupporting

confidence: 92%

Section: The Role Of Hbcs In Pregnancy Complicationsmentioning

confidence: 99%

Section: The Role Of Hbcs In Pregnancy Complicationsmentioning

confidence: 99%

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Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

2018

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“…Another study investigated CD14 and CD68 in addition to CD163 and DC-SIGN with a similar outcome, a reduction in all markers was observed, pointing towards decreased HBC numbers in PE. However, this study also observed decreased IL-10 production, which might be related to decreased HBC numbers, but might also suggest a shift to a more pro-inflammatory HBC phenotype [46].…”

Section: Discussionmentioning

confidence: 38%

Placental Hofbauer Cell Polarization Resists Inflammatory Cues In Vitro

Schliefsteiner

Ibesich

Wadsack

2020

IJMS

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Feto-placental Hofbauer cells (HBCs) are macrophages residing in placental stroma. They are generally described as anti-inflammatory M2 polarized cells, promoting tolerance and tissue remodeling. In certain pathologies, however, a possible phenotypical switch towards pro-inflammatory M1 macrophages has been proposed. The study aimed to determine if HBCs can acquire an M1 phenotype under pro-inflammatory conditions in vitro. HBCs were isolated from healthy human term placentas. Cells were cultivated upon addition of LPS and INF-γ or IL-4 and IL-13 to induce the M1 and M2 phenotype, respectively. Specific cell polarization markers and cytokines, associated with respective phenotypes, were investigated by flow cytometry and ELISA. THP-1 macrophages served as positive control. Pro-inflammatory stimuli reduced M2 markers CD163 and DC-SIGN, but did not induce M1 markers. TNF-α release was increased, but at the same time TGF-β and IL-10 release was upregulated, resembling in part the M2b sub-phenotype. Anti-inflammatory stimuli had no effect on HBC polarization. HBCs maintain their M2 phenotype in vitro despite inflammatory stimuli, which might represent a state of adaption and tolerance to avoid rejection of the semiallogeneic feto-placental unit.

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“…The placental villi have resident macrophages, namely, Hofbauer cells (HBCs), which have an M2 regulatory phenotype and play an essential role in controlling the inflammatory response in the course of pregnancy (61). HBCs expressing DC-SIGN produce IL-10 and are decreased in preeclampsia cases (62).…”

Section: Immune Cells In Placental Villimentioning

confidence: 99%

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

et al. 2020

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During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause congenital damage to the fetus. Recently, Zika virus (ZIKV) infection has gained great notoriety due to the occurrence of congenital ZIKV syndrome, characterized by fetal microcephaly, which results from the ability of ZIKV to infect placental cells and neural precursors in the fetus. Importantly, in addition to the congenital effects, studies have shown that perinatal ZIKV infection causes a number of disorders, including maculopapular rash, conjunctivitis, and arthralgia. In this paper, we contextualize the immunological aspects involved in the maternal-fetal interface and vulnerability to ZIKV infection, especially the alterations resulting in perinatal outcomes. This highlights the need to develop protective maternal vaccine strategies or interventions that are capable of preventing fetal or even neonatal infection.

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DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia

Cited by 57 publications

References 24 publications

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

Placental Hofbauer Cell Polarization Resists Inflammatory Cues In Vitro

Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

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