2023
DOI: 10.21203/rs.3.rs-2950076/v1
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DCAF1/VprBP triggers melanomagenic gene silencing through histone H2A phosphorylation

Abstract: DCAF1, also known as VprBP, is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing the risk for colon and prostate cancers. Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones. Here we demonstrate that DCAF1 is highly expressed and phosphorylates threonine 120 (T120) on histone H2A to driv… Show more

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