DCE-MRI of the breast in a stand-alone setting outside a complementary strategy - results of the TK-study

Kaiser, Ch.; Reich, Cornelia; Dietzel, Matthias; Baltzer, Pascal; Krammer, Julia; Wasser, K.; Schoenberg, Stefan O.; Kaiser, Werner A.

doi:10.1007/s00330-014-3580-4

Cited by 17 publications

(24 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) has been shown to be sensitive to changes in the physiological characteristics of tumor vasculature by providing quantifiable parameters, such as K trans (the volume transfer coefficient of contrast agent between the extracellular extravascular space (EES) and the blood plasma), K ep (a contrast agent backflux rate constant), Vp (plasma volume fraction), and V e (extravascular extracellular volume fraction). These characteristics potentially enable the use of DCE-MRI to diagnose [ 15 ] and manage solid tumors, including therapeutic effect monitoring [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin

et al. 2016

View full text Add to dashboard Cite

Our previous studies revealed molecular alterations of tumor vessels, varying from immature to mature alterations, resulting from Abraxane, and demonstrated that the integrin-specific PET tracer 18F-FPPRGD2 can be used to noninvasively monitor such changes. However, changes in the tumor vasculature at functional levels such as perfusion and permeability are also important for monitoring Abraxane treatment outcomes in patients with cancer. The purpose of this study is to further investigate the vascular response during Abraxane therapy and the effectiveness of its synergistic interaction with cisplatin using Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI). Thirty MDA-MB-435 tumor mice were randomized into three groups: PBS control (C group), Abraxane only (A group), and sequential treatment with Abraxane followed by cisplatin (A-P group). Tumor volume was monitored based on caliper measurements. A DCE-MRI protocol was performed at baseline and day 3. The Ktrans, Kep and Ve were calculated and compared with CD31, α-SMA, and Ki67 histology data. Sequential treatment with Abraxane followed by cisplatin produced a significantly greater inhibition of tumor growth during the three weeks of the observation period. Decreases in Ktrans and Kep for the A and A-P groups were observed on day 3. Immunohistological staining suggested vascular remodeling during the Abraxane therapy. The changes in Ktrans and Kep values were correlated with alterations in the permeability of the tumor vasculature induced by the Abraxane treatment. In conclusion, Abraxane-mediated permeability variations in tumor vasculature can be quantitatively visualized by DCE-MRI, making this a useful method for studying the effects of early cancer treatment, especially the early vascular response. Vascular remodeling by Abraxane improves the efficiency of cisplatin delivery and thus results in a favorable treatment outcome.

show abstract

Section: Introductionmentioning

confidence: 99%

DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, this overestimation was constant in repeated examinations, and thus should be considered when interpreting the FGT% findings (Figure ). To ensure a high patient throughput in clinical practice, short MRI protocols that do not exceed 15 min are required . In this context, the acquisition of additional sequences should be kept to a minimum.…”

Section: Discussionmentioning

confidence: 99%

“…To ensure a high patient throughput in clinical practice, short MRI protocols that do not exceed 15 min are required. 27,28 In this context, the acquisition of additional sequences should be kept to a minimum. The use of anisotropic Dixon sequences with a very high reproducibility facilitates the simultaneous acquisition of MRI data suitable for both diagnosis and accurate FGT measurement.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of fully automated, quantitative, volumetric measurement of the amount of fibroglandular breast tissue using MRI: correlation with anthropomorphic breast phantoms

et al. 2017

View full text Add to dashboard Cite

To demonstrate the accuracy of fully automated, quantitative, volumetric measurement of the amount of fibroglandular breast tissue (FGT), using MRI, and to investigate the impact of different MRI sequences using anthropomorphic breast phantoms as the ground truth. In this study, 10 anthropomorphic breast phantoms that consisted of different known fractions of adipose and protein tissue, which closely resembled normal breast parenchyma, were developed. Anthropomorphic breast phantoms were imaged with a 1.5 T unit (Siemens, Avantofit) using an 18-channel breast coil. The sequence protocol consisted of an isotropic Dixon sequence (Di), an anisotropic Dixon sequence (Da), and T 3D FLASH sequences with and without fat saturation (T1). Fully automated, quantitative, volumetric measurement of FGT for all anthropomorphic phantoms and sequences was performed and correlated with the amounts of fatty and protein components in the phantoms as the ground truth. Fully automated, quantitative, volumetric measurements of FGT with MRI for all sequences ranged from 5.86 to 61.05% (mean 33.36%). The isotropic Dixon sequence yielded the highest accuracy (median 0.51%-0.78%) and precision (median range 0.19%) compared with anisotropic Dixon (median 1.92%-2.09%; median range 0.55%) and T -weighted sequences (median 2.54%-2.46%; median range 0.82%). All sequences yielded good correlation with the FGT content of the anthropomorphic phantoms. The best correlation of FGT measurements was identified for Dixon sequences (Di, R = 0.999; Da, R = 0.998) compared with conventional T -weighted sequences (R = 0.971). MRI yields accurate, fully automated, quantitative, volumetric measurements of FGT, an increasingly important and sensitive imaging biomarker for breast cancer risk. Compared with conventional T sequences, Dixon-type sequences show the highest correlation and reproducibility for automated, quantitative, volumetric FGT measurements using anthropomorphic breast phantoms as the ground truth.

show abstract

“…Although MRM is internationally accepted to be the most accurate imaging tool in the detection of breast cancer, there is still a broad discussion about a general use of MRM for all women, i.e. screening especially since specificity and cost are much disputed [2], [3].…”

Section: Introductionmentioning

confidence: 99%

“…the general specificity of MRM could be raised to levels above 95% [3], suggesting that reader experience, and technical standards are prerequisites for “high-quality”- MRM [2].…”

Section: Introductionmentioning

confidence: 99%

The value of “constant sharpness” as a diagnostic sign in MR-Mammography

Kaiser

Baltzer

Kaiser

et al. 2016

European Journal of Radiology Open

Self Cite

View full text Add to dashboard Cite

PurposeTo examine “constant lesion sharpness” as a morphological diagnostic sign in the differential diagnosis between benign and malignant lesions.Material and methodsThis prospective study had institutional review board approval and was HIPAA compliant. In total 1014 consecutive patients were examined (mean age 55 years ± 13 years) and evaluated in our University hospital towards the morphological shape of the lesion borders. The “Constant sharpness Sign” was defined as a lesion remaining continuously sharp for the duration of the dynamic scan. Inclusion criteria were unclear findings (e.g. BIRADS III/IV), Preoperative staging (BRIDAS IV/V), and referred patients from local clinic of gynecology. Exclusion criteria were MRM-examination ≤1 year before, status after surgery and/or biopsy, chemotherapy and/or radiation therapy. Reference Standard was histological verification. Images were diagnosed by two experienced radiologists in consensus, blinded to the standard of reference.Results1014 patients with 1084 lesions (436 benign, 648 malignant lesions) were included into the study.41.5% of benign lesions and 6.8% (181/436) of malignant lesions displayed a constant sharpness as an accompanying morphological sign (P < 0.001). This resulted in a sensitivity of 41.5%, specificity of 93.2%, a positive likelihood ratio of 6.1%, a negative likelihood ratio of 0.63 and an odd’s ratio of 9,7%.Summary and conclusionThe constant sharpness sign seems to be an accurate predictor of benign breast lesions, which may help to increase the accuracy of MRM as a morphological sign.

show abstract

DCE-MRI of the breast in a stand-alone setting outside a complementary strategy - results of the TK-study

Cited by 17 publications

References 26 publications

DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin

DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin

Accuracy of fully automated, quantitative, volumetric measurement of the amount of fibroglandular breast tissue using MRI: correlation with anthropomorphic breast phantoms

The value of “constant sharpness” as a diagnostic sign in MR-Mammography

Contact Info

Product

Resources

About