DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8

Chen, Xian-Jun; Jiang, Yongan; Liu, Jiayu; Wang, Changfeng; Wan, Dengfeng; Liang, Aijun; Leng, Jingxing; Yang, Yu; Xiang, Hui; Liu, Ruen

doi:10.1155/2021/6568477

Cited by 12 publications

(4 citation statements)

References 58 publications

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“…Lin et al showed that sLOX-1 could effectively serve as a biomarker for DCI after aSAH [29], and Ding et al found that early neuroglobin levels may play a predictive role in the development of DCI [30]. Furthermore, our previous research confirmed that the expression level of patients with MFG-E8 in the serum of patients with aSAH was associated with the development of DCI [31].…”

Section: Discussionsupporting

confidence: 66%

Construction and Verification of a Risk Prediction Model for the Occurrence of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage Requiring Mechanical Ventilation

Chen

Leng

et al. 2023

BioMed Research International

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Objectives. Delayed cerebral ischemia (DCI) contributes to poor aneurysm prognosis. Subarachnoid hemorrhage and DCI have irreversible and severe consequences once they occur; therefore, early prediction and prevention are important. We investigated the risk factors for postoperative complications of DCI in patients with aneurysmal subarachnoid hemorrhage (aSAH) requiring mechanical ventilation in intensive care and validated a prediction model. Methods. We retrospectively analyzed patients with aSAH who were treated in a French university hospital neuro-ICU between January 2010 and December 2015. The patients were randomized into a training group (144) and verification groups (60). Nomograms were validated in the training and verification groups, where receiver operating characteristic curve analysis was used to verify model discrimination; calibration curve and Hosmer-Lemeshow test were used to determine model calibration; and decision curve analysis (DCA) was used to verify clinical validity of the model. Results. External ventricular drain (EVD), duration of mechanical ventilation, and treatment were significantly associated in the univariate analysis; EVD and rebleeding were significantly associated with the occurrence of DCI after aSAH. Binary logistic regression was used to select five clinicopathological characteristics to predict the occurrence of DCI in patients with aSAH requiring mechanical ventilation nomograms of the risk of DCI. Area under the curve values for the training and verification groups were 0.768 and 0.246, with Brier scores of 0.166 and 0.163, respectively. Hosmer-Lemeshow calibration test values for the training and verification groups were x 2 = 3.824 ( P = 0.923 ) and x 2 = 10.868 ( P = 0.285 ), respectively. Calibration curves showed good agreement. DCA indicated that the training and verification groups showed large positive returns in the broad risk range of 0-77% and 0-63%, respectively. Conclusions. The predictive model of concurrent DCI in aSAH has theoretical and practical values and can provide individualized treatment options for patients with aSAH who require mechanical ventilation.

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Section: Discussionsupporting

confidence: 66%

Construction and Verification of a Risk Prediction Model for the Occurrence of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage Requiring Mechanical Ventilation

Chen

Leng

et al. 2023

BioMed Research International

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“… 62 The levels were significantly higher in patients with sepsis, 54 type 2 diabetes mellitus, 63 SLE, 64 , 65 and aneurysmal subarachnoid hemorrhage. 66 In patients with cancer, the serum levels of MFG‐E8 were shown to be higher in patients with TNBC 67 but lower in patients with hepatocellular carcinoma. 68 Although multiple results have been reported as shown above, the meaning and pathophysiology for the regulation of systemic MFG‐E8 levels in these disease conditions have not been fully investigated.…”

Section: Discussionmentioning

confidence: 99%

“…The levels were significantly lower in patients with rheumatoid arthritis, 60 systemic sclerosis, 49 coronary atherosclerotic heart disease, 61 dilated cardiomyopathy, 52 and cerebral amyloid angiopathy 62 . The levels were significantly higher in patients with sepsis, 54 type 2 diabetes mellitus, 63 SLE, 64,65 and aneurysmal subarachnoid hemorrhage 66 . In patients with cancer, the serum levels of MFG‐E8 were shown to be higher in patients with TNBC 67 but lower in patients with hepatocellular carcinoma 68 .…”

Section: Discussionmentioning

confidence: 99%

Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG‐E8

Mizote,

Inoue,

Akazawa

et al. 2024

Cancer Science

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The direction and magnitude of immune responses are critically affected when dead cells are disposed of. Milk fat globule‐epidermal growth factor‐factor 8 (MFG‐E8) promotes the engulfment of apoptotic normal and cancerous cells without inducing inflammation. We have previously reported that a certain proportion of the cancer cells express abundant MFG‐E8, and that such expression is associated with the shorter survival of patients with esophageal cancer who had received chemotherapy before surgery. However, the influence of tumor‐derived and systemically existing MFG‐E8 on antitumor immune responses has not yet been fully investigated. Herein, we showed that CTL‐dependent antitumor immune responses were observed in mice with no or decreased levels of systemic MFG‐E8, and that such responses were enhanced further with the administration of anti‐PD‐1 antibody. In mice with decreased levels of systemic MFG‐E8, the dominance of regulatory T cells in tumor‐infiltrating lymphocytes was inverted to CD8+ T cell dominance. MFG‐E8 expression by tumor cells appears to affect antitumor immune responses only when the level of systemic MFG‐E8 is lower than the physiological status. We have also demonstrated in the clinical setting that lower levels of plasma MFG‐E8, but not MFG‐E8 expression in tumor cells, before the treatment was associated with objective responses to anti‐PD‐1 therapy in patients with non‐small cell lung cancer. These results suggest that systemic MFG‐E8 plays a critical role during the immunological initiation process of antigen‐presenting cells to increase tumor‐specific CTLs. Regulation of the systemic level of MFG‐E8 might induce efficient antitumor immune responses and enhance the potency of anti‐PD‐1 therapy.

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“…Delayed cerebral ischemia (DCI) is a serious complication after aSAH and can greatly increase the risk of poor prognosis in such patients. 2 Therefore, DCI prediction is of clinical benefit to aSAH management. During decades, biomarkers have been paid extensive attentions with respect to their aidance in severity assessment and prognostic prediction.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum NOX2 Levels Contribute to Delayed Cerebral Ischemia and a Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

Wang¹,

Ji²,

Wang³

et al. 2023

NDT

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Background NADPH oxidase 2 (NOX2) is highly expressed in injured brain tissues. We determined serum NOX2 levels of aneurysmal subarachnoid hemorrhage (aSAH) patients and further investigated correlation of serum NOX2 levels with disease severity, delayed cerebral ischemia (DCI) plus prognosis after aSAH. Methods Serum NOX2 levels were measured in 123 aSAH patients and 123 healthy controls. World Federation of Neurological Surgeons scale (WFNS) score and modified Fisher (mFisher) score were utilized to assess disease severity. Modified Rankin scale (mRS) score was used to evaluate the clinical prognosis at 90 days after aSAH. Relations of serum NOX2 levels to DCI and 90-day poor prognosis (mRS score of 3–6) were analyzed using multivariate analysis. Receiver operating characteristic curve (ROC) was built to evaluate the prognostic predictive capability. Results Serum NOX2 levels in aSAH patients, compared with healthy controls, were significantly increased, and were independently correlated with WFNS score, mFisher score and post-stroke 90-day mRS score. Patients with poor prognosis or DCI had significantly higher serum NOX2 levels than other remainders, and serum NOX2 levels independently predicted 90-day poor prognosis and DCI. Serum NOX2 had high prognosis and DCI predictive abilities, and their areas under ROC curve were similar to those of WFNS score and mFisher score. Conclusion Serum NOX2 levels are significantly associated with hemorrhage severity, poor 90-day prognosis and DCI in aSAH patients. Hence, complement NOX2 may serve as a potential prognostic biomarker after aSAH.

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DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8

Cited by 12 publications

References 58 publications

Construction and Verification of a Risk Prediction Model for the Occurrence of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage Requiring Mechanical Ventilation

Construction and Verification of a Risk Prediction Model for the Occurrence of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage Requiring Mechanical Ventilation

Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG‐E8

Elevated Serum NOX2 Levels Contribute to Delayed Cerebral Ischemia and a Poor Prognosis After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study

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