DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions

Longatto‐Filho, Adhemar; Pereira, Sônia Maria Miranda; Loreto, Celso di; Utagawa, Maria Lúcia; Makabe, Sérgio; Maeda, Marina Yoshiê Sakamoto; Marques, José António; Santoro, Carmen L.F.; Castelo, Adauto

doi:10.1016/j.ygyno.2005.01.013

Cited by 28 publications

(17 citation statements)

References 18 publications

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“…This study showed that the LBC method resulted in a significantly lower percentage of unsatisfactory specimens than the conventional method. Many prior reports have suggested that the LBC method produces a lower percentage of unsatisfactory specimens [1,2,3,4,5,6,7,8,9,10]. In studies reporting no difference in the reduction of unsatisfactory specimens, the rates were lower than those in a meta-analysis [16] and other reports (LBC method 0.3% vs. conventional method 1.1%) [17].…”

Section: Discussionmentioning

confidence: 91%

“…In addition, the Bethesda system (TBS; 2001), which outlines cytological diagnostic criteria for cervical smears, is only gradually being adopted. It has been reported that the liquid-based cytology (LBC) method is useful for reducing the number of unsatisfactory specimens [1,2,3,4,5,6,7,8,9,10]. Unsatisfactory specimens are ≤1.1%, and one of the most common reasons for unsatisfactory specimens was too few squamous cells [11].…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

et al. 2012

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Objective: To clarify the performance of liquid-based cytology (LBC) and conventional methods of preparing cervical specimens for cytological screening. Study Design: We studied 236,511 patients who participated in a population-based cervical cancer screening program conducted in the Niigata prefecture between 2005 and 2008. The percentage of unsatisfactory specimens and the disease detection rate were compared between specimens prepared by LBC and conventional methods. Results: (1) The LBC method demonstrated a significantly lower percentage of unsatisfactory specimens than the conventional method (1.38 and 11.45%, respectively; p < 0.01). (2) Among the initial women, tumor lesions were detected in 0.57% of those examined with the LBC method, which was significantly higher than the positivity rate of those examined with the conventional method (0.25%; p < 0.05). Among the women with repeat screening, disease was detected in 0.08% of those examined with LBC twice, which was significantly lower than the positivity rates for those examined with the conventional method followed by the LBC method (0.11%) or the conventional method twice (0.16%; p < 0.05). Conclusion: The LBC method is significantly more useful than the conventional method in terms of the low adequacy rate and the high detection rate of cancer in cervical cancer screening in a localized area in Japan.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

et al. 2012

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“…However, when LBC and conventional smears have been measured against a biopsy-proven result, the differences have not shown significant improvements in terms of ameliorated performance in other reports from developed countries [10]. However, this assumption is not necessarily true for poorer settings [1]. The reasons for these discrepancies could be attributed to several factors, and most of those factors have been discussed previously.…”

Section: Discussionmentioning

confidence: 98%

“…The impassioned disputes between defenders of conventional Pap smears and those who believe in the supremacy of liquid-based cytology (LBC) are generally supported by the belief that one of these methods has the potential to detect more cases of high-grade squamous intraepithelial lesions (HSILs) on routine screenings for cervical cancer even in high-risk settings [1]. Moreover, LBC is believed to improve the quality of sample preparations, be more cost-effective, allow the use of computer-assisted screening and provide residual material for ancillary testing, including human papillomavirus (HPV) testing, all of which strongly favor the use of LBC [2,3,4].…”

Section: Introductionmentioning

confidence: 99%

The Significance of Augmented High-Grade Squamous Intraepithelial Lesion Detection on Pap Test Examination: Partial Results from the RODEO Study Team

et al. 2013

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Objective: This study sought to ascertain the significance of augmented high-grade squamous intraepithelial lesion (HSIL) detection by Pap test using both conventional smear and liquid-based cytology (LBC) in a high-risk population. Study Design: We conducted a direct-to-vial study to compare the diagnostic performance of Pap smear versus LBC in a high-risk population of women referred for colposcopy at a gynecologic ambulatory clinic at the Barretos Cancer Hospital in Brazil during 2011. Results: The detection of both low-grade squamous intraepithelial lesions (LSILs) and HSILs was significantly greater (p = 0.04 and p = 0.033, respectively) in the LBC arm [84 LSIL cases (5.7%) and 148 HSIL cases (10.1%)] than in the conventional smear arm [66 LSIL cases (4.1%) and 126 HSIL cases (7.9%)]; however, no differences were found for invasive squamous carcinoma or adenocarcinoma (p = 0.678). Of 3,071 women who were examined cytologically (1,604 conventional preparations and 1,467 LBC) and colposcopically, biopsies were available for 279 conventional preparations (17.6%) and 325 LBC preparations (22.2%). No significant differences were found between the methods with respect to diagnostic performance. Conclusion: LBC was significantly superior to conventional smears for the detection of LSILs and HSILs, but these results did not influence biopsy confirmation. Both methods showed similar performances with high positive predictive values but very low sensitivities.

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“…If ASC-US and ASC-H are not taken into consideration, the LSIL + HSIL proportions for LBC remain twice that of CPT (1.1 vs. 0.5%). Among high-risk Brazilian women, LBC has been shown to outperform CPT [9]; however, its superiority has not been borne out among low-risk women [9,10,11,12]. Nonetheless, in the setting of a community whose population numbers in the millions, small proportional differences equate to significant differences among actual patients.…”

Section: Discussionmentioning

confidence: 99%

Could Alarmingly High Rates of Negative Diagnoses in Remote Rural Areas Be Minimized with Liquid-Based Cytology? Preliminary Results from the RODEO Study Team

et al. 2012

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Objective: It was the aim of this study to compare diagnostic performances of the BD SurePath™ liquid-based Papanicolaou test (LBC) and the conventional Papanicolaou test (CPT) in cervical samples of women from remote rural areas of Brazil. Study Design: Specimens were collected by mobile units provided by Barretos Cancer Hospital. This report evaluates the manual screening arm of the RODEO study. Of 12,048 women seen between May and December 2010, 6,001 were examined using LBC and 6,047 using CPT. Results: Comparative (LBC vs. CPT) outcomes were: all abnormal tests, 2.1 versus 1.0%; ASC-US (atypical squamous cells of unknown significance), 0.7 versus 0.1%; ASC-H (atypical squamous cells with possible high-grade squamous intraepithelial lesions) and AGC (atypical glandular cells), 0.4 versus 0.3%; LSIL (low-grade squamous intraepithelial lesions), 0.7 versus 0.3%; HSIL (high-grade squamous intraepithelial lesions), 0.4 versus 0.2%, and unsatisfactory, 0.03 versus 0.08%. The LBC arm detected significantly more lesions (ASC-US+) than CPT (p < 0.001); however, when we divided the diagnoses into two groups, ASC-H– (negative/ASC-US/LSIL) and ASC-H+ (ASC-H/AGC/HSIL), the difference was not statistically important (p = 0.213). Conclusions: With inherent difficulties in patient recruitment and patient compliance with cancer screening, best test performance including human papillomavirus test capability are vitally necessary in Brazil’s struggle to reduce cervical cancer.

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DCS liquid-based system is more effective than conventional smears to diagnosis of cervical lesions

Abstract: This study confirms the superiority of the liquid-based cytology system DCS to detect cervical lesions. The rate of adequate DSC slides was significantly higher than with conventional cytology.

Cited by 28 publications

References 18 publications

A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

The Significance of Augmented High-Grade Squamous Intraepithelial Lesion Detection on Pap Test Examination: Partial Results from the RODEO Study Team

Could Alarmingly High Rates of Negative Diagnoses in Remote Rural Areas Be Minimized with Liquid-Based Cytology? Preliminary Results from the RODEO Study Team

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