DD genotype of the I/D Angiotensin-Converting Enzyme Gene Polymorphism  is a higher Risk for Atopic Asthma

Iskandar, Harun

doi:10.5455/ijmrcr.atopic-asthma-ace-gene-polymorphism

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“…The ACE gene is located on the q23 locus of chromosome 17. Individual variability in the plasma ACE levels is associated with a presence showed that ACE D/D genotype had significantly higher occurrence in atopic asthmatic patients, compared to healthy control subjects; patients with D/D genotype had 6.8-fold higher risk for atopic asthma development than those with non-D/D genotype [36]. Pasiyeshvili and Zheleznyakova showed that the relative risk of developing BA was 2.67 for patients with the ACE D/D genotype; 0.46 for the ACE D/I genotype; and 0.69 for the ACE I/I genotype, suggesting a possible protective role of the I allele [37].…”

Section: Introductionmentioning

confidence: 99%

Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

Krynytska

Mykolenko

Smachylo

et al. 2021

Open Access Maced J Med Sci

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Researching bronchial asthma (BA)-linked gene polymorphisms can help to clarify heterogeneity of the disease and estimate its severity, which, in turn, will aid in developing an appropriate treatment corresponding to the patient’s unique asthma pathogenesis. The aim of presented review is to analyze the published data on the genetic preconditions of BA and the possible role of different genes polymorphisms in its pathogenesis. We have found that despite the fact that numerous genes are involved in the pathogenesis of BA and their polymorphisms are associated with increased risks for BA, it is important to understand that a combination of factors, both genetic and environmental, triggers BA development and determines its progression. On the other hand, the identification of BA susceptibility genes contributing to asthma pathogenesis and treatment response is the first step toward the development of personalized medicine.

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Section: Introductionmentioning

confidence: 99%