DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis

Yuan, Juntao; Yu, Zhuoran; Zhang, Ping; Luo, Kai; Xu, Ying; Lan, Ting; Zhang, Min; Chen, Yingjie; Lu, Zhongbing

doi:10.1016/j.redox.2024.103080

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Peroxiredoxins and Thioredoxins1

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2024

2025

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Cited by 2 publications

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“…So far, two PRDXs have been described in OS: PRDX2, which contributes to resistance to chemotherapy, malignancy, and poor prognosis [113], and PRDX1 with conflicting results [114,115]. Some data suggest that the overexpression of PRDX1 and SRX1 may protect the liver from CCl4-induced toxicity, and reduce the amount of 4-HNE [116].…”

Section: Peroxiredoxins and Thioredoxinsmentioning

confidence: 99%

Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

Borović Šunjić,

Jaganjac,

Vlainić

et al. 2024

IJMS

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Oxidative stress and lipid peroxidation play important roles in numerous physiological and pathological processes, while the bioactive products of lipid peroxidation, lipid hydroperoxides and reactive aldehydes, act as important mediators of redox signaling in normal and malignant cells. Many types of cancer, including osteosarcoma, express altered redox signaling pathways. Such redox signaling pathways protect cancer cells from the cytotoxic effects of oxidative stress, thus supporting malignant transformation, and eventually from cytotoxic anticancer therapies associated with oxidative stress. In this review, we aim to explore the status of lipid peroxidation in osteosarcoma and highlight the involvement of lipid peroxidation products in redox signaling pathways, including the involvement of lipid peroxidation in osteosarcoma therapies.

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