Ddavp (1-Desamino-8-D-Arginine Vasopressin) Decreases Operative Blood Loss in Patients Undergoing Harrington Rod Spinal Fusion Surgery

Abstract

A is an X-linked disorder caused by absent or dysfunctional factor VII1:C.Because of therapy-induced complications: hepatitis, inhibitor formation, and infection with Human Immunodeficiency Virus, CS determination is often requested. CS by analysis of factor VII1:C levels and pedigree-derived probabilities has limited utility and significant risk for error. We evaluated the utility of 3 intraqenic restriction fragment length polymorphisms (RFLPs) (Intron 18, 22 and 2 5 ) and the closely-linked extragenic RFLP (ST14) to provide CS through genotype assignment. Using standard Southern blots we found that 3 8 / 9 3 ( 4 1 % ) , 2 5 / 4 3 ( 5 8 % ) , 1 4 / 4 4