2022
DOI: 10.3389/fcell.2022.919438
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dDAVP Downregulates the AQP3-Mediated Glycerol Transport via V1aR in Human Colon HCT8 Cells

Abstract: Vasopressin (AVP) plays a key function in controlling body water and salt balance through the activation of the vasopressin receptors V1aR and V2R. Abnormal secretion of AVP can cause the syndrome of inappropriate antidiuresis that leads to hyponatremia, which is an electrolyte disorder often observed in the elderly hospitalized and oncologic patients. Beyond kidneys, the colonic epithelium modulates water and salt homeostasis. The water channel AQP3, expressed in villus epithelial cells is implicated in water… Show more

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Cited by 2 publications
(1 citation statement)
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“…MMECs were co-cultured with FBEVs labelled with the cell membrane tracker BODIPY TR ceramide (Thermo Fisher Scientific) for 3, 6, 12, and 24 h. Next, MMECs were fixed with 4% paraformaldehyde, permeabilized with Triton-X100 and then incubated with phalloidin-FITC (Sigma-Aldrich) for F-actin staining. Images were acquired with a confocal laser-scanning fluorescence microscope Leica TCS SP2 (Leica Microsystems, Heerbrugg, Switzerland) as previously described [16].…”
Section: Immunofluorescence-confocal Laser-scanning Microscopymentioning
confidence: 99%
“…MMECs were co-cultured with FBEVs labelled with the cell membrane tracker BODIPY TR ceramide (Thermo Fisher Scientific) for 3, 6, 12, and 24 h. Next, MMECs were fixed with 4% paraformaldehyde, permeabilized with Triton-X100 and then incubated with phalloidin-FITC (Sigma-Aldrich) for F-actin staining. Images were acquired with a confocal laser-scanning fluorescence microscope Leica TCS SP2 (Leica Microsystems, Heerbrugg, Switzerland) as previously described [16].…”
Section: Immunofluorescence-confocal Laser-scanning Microscopymentioning
confidence: 99%