DDT-related compounds as non-extractable residues in submarine sediments of the Palos Verdes Shelf, California, USA

Kucher, Sebastian; Schwarzbauer, Jan

doi:10.1016/j.chemosphere.2017.07.041

Cited by 22 publications

(9 citation statements)

References 28 publications

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“…The extracts from the aforementioned three solvents were combined and rotary evaporated at room temperature to reduce the volume. After drying by anhydrous sodium sulfate (Na 2 SO 4 ) and the removal of elemental sulfur with activated cooper powder, each extract was separated into six factions by micro silica column chromatography using mixtures of n -pentane, dichloromethane and methanol as eluents, as formerly described in detail . A surrogate standard containing 5.82 ng μL –1 4′-fluoroacetophenone, 6.28 ng μL –1 d 10 -benzophenone and 6.03 ng μL –1 d 34 -hexadecane was added to each fraction before gas chromatography–mass spectrometry (GC–MS) analyses.…”

Section: Methodsmentioning

confidence: 99%

“…The formation potential and bioavailability of nonextractable DDT in soil have been investigated for decades, and the 14 C-labeling was the mainstream approach. − With this approach it was proved that NER-DDT and NER-DDE are formed in soil under different matrix conditions, can be released to a low extent and are potentially bioavailable for plants. Sequential chemical degradation has been applied since 2003 to release sedimentary bound DDXs, and a variety of DDT metabolites have been detectable as NER. − More recently, pyrolysis and thermochemolysis have been conducted to obtain further DDT derivatives . Covalent linkage of DDA (dichlorodiphenylacetic acid) to soil and sediment, which forms NER-DDA was proved by Kalathoor et al in 2015 .…”

Section: Introductionmentioning

confidence: 99%

“…For a better understanding of the fate of NER-DDXs, soil, sediment and groundwater sludge samples from two highly DDT-contaminated areas were therefore collected for this study to investigate the distribution variation of NER-DDXs. Solvent extraction and sequential chemical degradation, which have been well developed, ,,, were applied on these samples to obtain extractable and nonextractable DDXs, respectively. TMAH (tetramethylammonium hydroxide) thermochemolysis was also conducted to obtain further NER-DDT derivatives.…”

Section: Introductionmentioning

confidence: 99%

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Formation and Fate of Point-Source Nonextractable DDT-Related Compounds on Their Environmental Aquatic-Terrestrial Pathway

Zhu

Dsikowitzky

Kucher

et al. 2019

Environ. Sci. Technol.

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Nonextractable residues (NER) are pollutants incorporated into the matrix of natural solid matter via different binding mechanisms. They can become bioavailable or remobilize during physical−chemical changes of the surrounding conditions and should thus not be neglected in environmental risk assessment. Sediments, soils, and groundwater sludge contaminated with DDXs (DDT, dichlorodiphenyltrichloroethane; and its metabolites) were treated with solvent extraction, sequential chemical degradation, and thermochemolysis to study the fate of NER-DDX along different environmental aquatic-terrestrial pathways. The results showed that DDT and its first degradation products, DDD (dichlorodiphenyldichloroethane) and DDE (dichlorodiphenyldichloroethylene), were dominant in the free extractable fraction, whereas DDM (dichlorodiphenylmethane), DBP (dichlorobenzophenone), and DDA (dichlorodiphenylacetic acid) were observed primarily after chemical degradation. The detection of DDA, DDMUBr (bis(p-chlorophenyl)bromoethylene), DDPU (bis(p-chlorophenyl)-propene) and DDPS (bis(p-chlorophenyl)-propane) after chemical treatments evidenced the covalent bindings between these DDXs and the organic matrix. The identified NER-DDXs were categorized into three groups according to the three-step degradation process of DDT. Their distribution along the different pathways demonstrated significant specificity. Based on the obtained results, a conceptual model of the fate of NER-DDXs on their different environmental aquatic-terrestrial pathways is proposed. This model provides basic knowledge for risk assessment and remediation of both extractable and nonextractable DDT-related contaminations.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formation and Fate of Point-Source Nonextractable DDT-Related Compounds on Their Environmental Aquatic-Terrestrial Pathway

Zhu

Dsikowitzky

Kucher

et al. 2019

Environ. Sci. Technol.

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“…Các hóa chất bảo vệ thực vật thuộc loại POPs đã được sử dụng nhiều trong sản xuất nông nghiệp ở nước ta cũng như nhiều nước khác trên thế giới [1][2][3]. Dư lượng các chất này trong đất, nước ở nhiều khu vực còn rất cao và cần được xử lý [4,5]. Các hợp chất POPs đa phần là các dẫn xuất halogen, tương đối bền vững và khó phân hủy sinh học.…”

Section: Giới Thiệu Chungunclassified

A theoretical study on the adsorption of dichlorodiphenyltrichloroethane (DDT) on graphitic carbon nitride (g-C3N4) and g-C3N4 modified with cluster Ni2

Thi¹,

Thu²,

Ngoc³

2021

Vietnam j. catal. adsorp.

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A robust and accurate tight-binding quantum chemical method was performed to study adsorption process of dichlorodiphenyltrichloroethane (DDT) on graphitic carbon nitride (g-C3N4) and g-C3N4 modified with nickel cluster (Ni2). The adsorption energy, charges on atoms, bond orders have been calculated and analysed. The obtained results indicate that the adsorption of DDT on the pristine g-C3N4 is physical of nature. Ni2 cluster can be easily doped on g-C3N4 due to the formation of chemical bonds. The Ni2-g-C3N4 system exhibits enhanced adsorption ability for DDT.

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“…Although the use and production of DDT has been eliminated from most countries, the World Health Organization (WHO) has sanctioned the pesticide for indoor use as part of Integrated Vector Management to control vector-borne diseases such as malaria (EPA, 2017). Its environmental persistence in combination with improper disposal of legacy sources, exemplified by the Montrose, Del Amo and the Palos Verdes Superfund sites in Southern California, continue to contribute a heavy environmental burden of the pesticide and pose health risks even in the United States (Coffin et al, 2017;Kucher and Schwarzbauer, 2017).…”

mentioning

confidence: 99%

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

Truong

Cherednichenko

Pessah

2019

Toxicological Sciences

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Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-gated sodium channels, it mediates toxicity in mammals by acting as an endocrine disruptor (ED). Numerous studies demonstrate DDT/DDE to be EDs, but studies examining muscle-specific effects mediated by nonhormonal receptors in mammals are lacking. Therefore, we investigated whether o,p′-DDT, p,p′-DDT, o,p′-DDE, and p,p′-DDE (DDx, collectively) alter the function of ryanodine receptor type 1 (RyR1), a protein critical for skeletal muscle excitation-contraction coupling and muscle health. DDx (0.01–10 µM) elicited concentration-dependent increases in [3H]ryanodine ([3H]Ry) binding to RyR1 with o,p′-DDE showing highest potency and efficacy. DDx also showed sex differences in [3H]Ry-binding efficacy toward RyR1, where [3H]Ry-binding in female muscle preparations was greater than male counterparts. Measurements of Ca2+ transport across sarcoplasmic reticulum (SR) membrane vesicles further confirmed DDx can selectively engage with RyR1 to cause Ca2+ efflux from SR stores. DDx also disrupts RyR1-signaling in HEK293T cells stably expressing RyR1 (HEK-RyR1). Pretreatment with DDx (0.1–10 µM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner. o,p′-DDE (24 h; 1 µM) significantly increased Ca2+-transient amplitude from electrically stimulated mouse myotubes compared with control and displayed abnormal fatigability. In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health.

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DDT-related compounds as non-extractable residues in submarine sediments of the Palos Verdes Shelf, California, USA

Cited by 22 publications

References 28 publications

Formation and Fate of Point-Source Nonextractable DDT-Related Compounds on Their Environmental Aquatic-Terrestrial Pathway

Formation and Fate of Point-Source Nonextractable DDT-Related Compounds on Their Environmental Aquatic-Terrestrial Pathway

A theoretical study on the adsorption of dichlorodiphenyltrichloroethane (DDT) on graphitic carbon nitride (g-C3N4) and g-C3N4 modified with cluster Ni2

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

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