2024
DOI: 10.3390/ijms252413581
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DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications

Yalan Xiao,
Jiankun Fan,
Zhigang Li
et al.

Abstract: DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. Its diverse functions in cancer progression and viral infections have attracted considerable attention. DDX21 exerts a pivotal function through ribosomal DNA (rDNA) transcription and rRNA processing. DDX21 is involved in different biological processes of mRNA transcription. It interacts with transcription factors, modulates RN… Show more

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