De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing

Agrawal, Rashi; Bollag, Wendy B.

doi:10.1016/j.jlr.2022.100231

Cited by 2 publications

(2 citation statements)

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“…The acceleration of wound healing through CERK inhibition with SYR382141 appeared to be linked, at least partially, to observed increases in fibroblast activation protein expression, the influx of infiltrating cells, and the deposition of type 1 collagen [134]. These findings suggest that inhibiting the formation of CERK-derived C1P may prompt a shift from the inflammatory stage to the proliferation phase, a crucial transition for effective wound healing [135].…”

Section: Lipids In Keratinocyte and Fibroblast Migration And Prolifer...mentioning

confidence: 84%

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Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process

Choudhary,

Bollag

2024

IJMS

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Cutaneous wound healing is a complex biological process involving a series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying skin wound repair and to evaluate potential therapeutic interventions. This review explores the diverse array of skin wound healing models utilized in research, ranging from rodent excisional wounds to advanced tissue engineering constructs and microfluidic platforms. More importantly, the influence of lipids on the wound healing process is examined, emphasizing their role in enhancing barrier function restoration, modulating inflammation, promoting cell proliferation, and promoting remodeling. Lipids, such as phospholipids, sphingolipids, and ceramides, play crucial roles in membrane structure, cell signaling, and tissue repair. Understanding the interplay between lipids and the wound microenvironment provides valuable insights into the development of novel therapeutic strategies for promoting efficient wound healing and tissue regeneration. This review highlights the significance of investigating skin wound healing models and elucidating the intricate involvement of lipids in the healing process, offering potential avenues for improving clinical outcomes in wound management.

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Section: Lipids In Keratinocyte and Fibroblast Migration And Prolifer...mentioning

confidence: 84%

“…Mediates inflammation through stimulation of cytosolic phospholipase A 2 and the subsequent release of arachidonic acid and prostaglandin formation [96]. Serves as a checkpoint for phase transition from the inflammation to the proliferation phase [134,135].…”

Section: Promotion Of Inflammationmentioning

confidence: 99%