Abstract:Empiric broad-spectrum antimicrobials therapy is suggested to be started
immediately for sepsis patients. Empiric antimicrobial therapy should be
narrowed once pathogen identification and sensitivities are established.
However, the detail mechanisms of de-escalation strategy are still
unclear. Here we hypothesized neutrophil extracellular trap (NETs)
played an essential role and de-escalation strategy might alleviate
organs injury through regulation of NETs formation in sepsis. We
evaluated the effect of imipe… Show more
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