De la neurastenia a la enfermedad postesfuerzo: evolución de los criterios diagnósticos del síndrome de fatiga crónica/encefalomielitis miálgica

Murga, Íñigo; Lafuente, José Vicente

doi:10.1016/j.aprim.2019.04.004

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Similar clinical presentations have appeared recently in descriptions of patient outcomes some months after suffering from COVID-19 (2). Similar descriptions can be found in the literature under names such as epidemic neuromyasthenia, vegetative neuritis, post-viral fatigue syndrome, raphe nucleus encephalopathy, chronic mononucleosis syndrome or exertion intolerance, among others (3). These conditions can arise in isolated form, but generally appear within the context of epidemics (4).…”

Section: Introductionsupporting

confidence: 72%

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue

et al. 2021

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The aim of present paper is to identify clinical phenotypes in a cohort of patients affected of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Ninety-one patients and 22 healthy controls were studied with the following questionnaires, in addition to medical history: visual analogical scale for fatigue and pain, DePaul questionnaire (post-exertional malaise, immune, neuroendocrine), Pittsburgh sleep quality index, COMPASS-31 (dysautonomia), Montreal cognitive assessment, Toulouse-Piéron test (attention), Hospital Anxiety and Depression test and Karnofsky scale. Co-morbidities and drugs-intake were also recorded. A hierarchical clustering with clinical results was performed. Final study group was made up of 84 patients, mean age 44.41 ± 9.37 years (66 female/18 male) and 22 controls, mean age 45 ± 13.15 years (14 female/8 male). Patients meet diagnostic criteria of Fukuda-1994 and Carruthers-2011. Clustering analysis identify five phenotypes. Two groups without fibromyalgia were differentiated by various levels of anxiety and depression (13 and 20 patients). The other three groups present fibromyalgia plus a patient without it, but with high scores in pain scale, they were segregated by prevalence of dysautonomia (17), neuroendocrine (15), and immunological affectation (19). Regarding gender, women showed higher scores than men in cognition, pain level and depressive syndrome. Mathematical tools are a suitable approach to objectify some elusive features in order to understand the syndrome. Clustering unveils phenotypes combining fibromyalgia with varying degrees of dysautonomia, neuroendocrine or immune features and absence of fibromyalgia with high or low levels of anxiety-depression. There is no a specific phenotype for women or men.

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Section: Introductionsupporting

confidence: 72%

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue

et al. 2021

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“…The nomenclature, classification, and diagnostic criteria have undergone various changes [ 14 , 15 ]. The most recent change took place in 2015 when the US National Academy of Medicine proposed the name of Systemic Exertion Intolerance Disease [ 16 ], a hybrid between the criteria for CFS (detailed by Fukuda, 1994) and ME (detailed by Carruthers, 2011), which does not solve the lack of definition of the syndrome.…”

Section: Introductionmentioning

confidence: 99%

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

et al. 2021

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disorder of unknown physiopathology with multisystemic repercussions, framed in ICD-11 under the heading of neurology (8E49). There is no specific test to support its clinical diagnosis. Our objective is to review the evidence in neuroimaging and dysautonomia evaluation in order to support the neurological involvement and to find biomarkers serving to identify and/or monitor the pathology. The symptoms typically appear acutely, although they can develop progressively over years; an essential trait for diagnosis is “central” fatigue together with physical and/or mental exhaustion after a small effort. Neuroimaging reveals various morphological, connectivity, metabolic, and functional alterations of low specificity, which can serve to complement the neurological study of the patient. The COMPASS-31 questionnaire is a useful tool to triage patients under suspect of dysautonomia, at which point they may be redirected for deeper evaluation. Recently, alterations in heart rate variability, the Valsalva maneuver, and the tilt table test, together with the presence of serum autoantibodies against adrenergic, cholinergic, and serotonin receptors were shown in a subgroup of patients. This approach provides a way to identify patient phenotypes. Broader studies are needed to establish the level of sensitivity and specificity necessary for their validation. Neuroimaging contributes scarcely to the diagnosis, and this depends on the identification of specific changes. On the other hand, dysautonomia studies, carried out in specialized units, are highly promising in order to support the diagnosis and to identify potential biomarkers. ME/CFS orients towards a functional pathology that mainly involves the autonomic nervous system, although not exclusively.

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“…Este síndrome es objeto de estudio en varios países y se ajusta a la clasificación de los problemas relacionados con los afrontamientos a las dificultades de la vida. Murga & Lafuente (2019), informan que en Europa se le diagnostica como el síndrome de neurastenia pero con la condición de que su sintomatología se asocie al trabajo quienes lo catalogan como enfermedad mental.…”

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El síndrome de burnout y sus consecuencias en la salud mental de los docentes

et al. 2021

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La educación es un proceso que demanda docentes preparados, capacitados, poseedores de valores, pero también con una adecuada salud mental. Estos aspectos son medulares en la formación de los niños, niñas y jóvenes. El Instituto Superior Tecnológico, propuso un proyecto de investigación cuyo tema es: Alternativas de desafíos contra el síndrome Burnout. La propuesta pretende mejorar la salud mental y emocional dirigida a los docentes de Portoviejo- Manabí, con un alcance de dos años, que culmina en el 2022. La propuesta es innovadora, pertinente, actual y contextualizada, que responde a las necesidades de la provincia y del cantón. El objetivo del estudio fue proponer un sistema de acciones encaminado a la prevención del síndrome de burnout en los docentes de unidades educativas fiscales del cantón Portoviejo. Se aplicó una metodología inherente a un estudio descriptivo, prospectivo y transversal en 200 docentes de instituciones fiscales, donde los docentes se encontraron sensiblemente afectados, los principales síntomas identificados fueron, agotamiento físico y mental, falta de motivación absoluta, sensibilidad a la crítica, pérdida de energía, descenso en la productividad laboral y estrés. En la teoría hubo divergencia de las opiniones, considerándose el síndrome de burnout como una patología mental crónica y/o aguda, la investigación permitió valorarla como aguda, en tanto se intervenga en pos de la salud mental. Se concluye que la encuesta arrojó información dirigida a una propuesta operativa de sistema de acciones encaminado a la prevención del síndrome de burnout en los docentes de unidades educativas fiscales del cantón Portoviejo.

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De la neurastenia a la enfermedad postesfuerzo: evolución de los criterios diagnósticos del síndrome de fatiga crónica/encefalomielitis miálgica

Cited by 7 publications

References 17 publications

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity?

El síndrome de burnout y sus consecuencias en la salud mental de los docentes

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