De novo acute myeloid leukemia with monocytoid blasts and erythrophagocytosis

Blieden, Clifford; Fan, Yao Shan; Chapman, Jennifer R.; Vega, Francisco

doi:10.1002/ccr3.120

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…15 The pathogenic mechanism related to this behavior in neoplastic cells remains unclear, although associations have been found with some chromosomal abnormalities such as t (16;21) and t(8;16). [18][19][20] This behavior was present in blasts of the patient presented in this case report and could be attributed to the complex cytogenetic aberrations acquired after treatment, including chromosomes 8p and 16q.…”

Section: Discussionmentioning

confidence: 60%

Hemophagocytosis by Blasts in a Child With Acute Monocytic Leukemia After Chemotherapy

Farias

Freitas

Spagnol

et al. 2021

Rev. paul. pediatr.

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Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia.

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Section: Discussionmentioning

confidence: 60%

Hemophagocytosis by Blasts in a Child With Acute Monocytic Leukemia After Chemotherapy

Farias

Freitas

Spagnol

et al. 2021

Rev. paul. pediatr.

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“…Blast hemophagocytosis is mostly reported at the time of the onset and is associated to abnormal karyotype [1,[3][4][5][6][7][8][9]11], it rarely happens after chemotherapy, as in our case, and seems to be associated to karyotype evolution in patients presenting with normal karyotype at the onset [1].…”

Section: Discussionmentioning

confidence: 65%

“…The percentage of blasts involved may vary extremely, from 0.2 to 36.7% [1,[3][4][5][6][7][8][9]11]. The specificity of blast hemophagocytosis is controversial and cases reported in the literature do not mention any specific explorations or dedicated treatment as in M-HLH [3,11,13].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism behind this blast's behavior remains unclear and associations have been found with some chromosomal abnormalities, especially t (8;16), but also with other translocations as t(10;17), t(16;21), t (3;8;17) and t(3;8) regardless of the morphological type; M0, M1, M4, M5a, M5b or even M7 [1,[3][4][5][6][7][8]. Many mechanisms have been suggested by authors as the expression of binding receptors involved in hemophagocytosis, karyotype evolution related to genetic instability and treatment toxicity [2,3,6,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Sayagh¹,

Cherrafi²,

Siboub³

et al. 2022

AJLM

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Hemophagocytosis is a property of histiocytic lineage cells; it is rarely performed by leukemic blasts. This phenomenon happens in approximately 1% of acute leukemias, particularly acute myeloid leukemia (AML) and especially those of monoblastic or monocytic lineage. Associations have been found with some chromosomal abnormalities, especially t(8;16). The presence of blast hemophagocytosis may speed-up the diagnosis of some of these cytogenetic abnormalities. We aim to report a case of peripheral blood blast erythrophagocytosis after chemotherapy for the treatment of acute monoblastic leukemia. It is about 29 years old male treated for acute monoblastic leukemia without chromosomal abnormalities at the onset, with two relapses for the first and second induction cures. Peripheral blood smear performed during the follow up showed 73% of blasts, 3.6% of them with erythrophagocytosis. Several genetic abnormalities are known to be associated to leukemic cell hemophagocytosis, involving particularly the chromosome 8 and explaining a part of the leukemogenesis. These abnormalities are rare and associated to a poor prognosis. The mechanism behind this blast behavior is still unclear and authors suggest some hypothesis to explain this phenomenon: the presence of binding receptors involved in phagocytosis on blasts, karyotype instability and evolution during the course of the disease and the involvement of treatment toxicity.

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“…Furthermore, Crebbp +/‐ mice exhibit similar abnormalities in bones and neuronal tissues, defects in B‐lymphoid development and an increased tendency for haematopoietic malignancy with age . Additionally, CREBBP mutations were discovered in B‐cell lymphoma such as follicular lymphoma (FL) and diffuse large B‐cell lymphoma (DLBCL), and CREBBP chromosomal translocations were found in myelodysplastic syndrome, therapy‐related acute myeloid leukaemia (AML), de novo AML and ALL . All these findings suggest that lost or diminished CREBBP function is correlated with haematologic or lymphoid tissue malignancy.…”

Section: Introductionmentioning

confidence: 97%

Low CREBBP expression is associated with adverse long‐term outcomes in paediatric acute lymphoblastic leukaemia

Gao

Zhang²,

Zhao³

et al. 2017

European J of Haematology

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De novo acute myeloid leukemia with monocytoid blasts and erythrophagocytosis

Abstract: Key Clinical MessageAcute myeloid leukemia (AML) with t(8:16) is an infrequent acute leukemia subtype. It can occur de novo or more frequently therapy-related. The presence of blasts with monocytoid morphology and erythrophagocytosis suggest the presence of the t(8;16).

Cited by 7 publications

References 4 publications

Hemophagocytosis by Blasts in a Child With Acute Monocytic Leukemia After Chemotherapy

Hemophagocytosis by Blasts in a Child With Acute Monocytic Leukemia After Chemotherapy

Peripheral Blood Blast Erythrophagocytosis After Chemotherapy in a Patient with Acute Monoblastic Leukemia

Low CREBBP expression is associated with adverse long‐term outcomes in paediatric acute lymphoblastic leukaemia

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