De novo adipogenesis using a bioabsorbable implant without additional cells or growth factors

Ogino, Shuichi; Sakamoto, Michiharu; Lee, Sung‐Hee; Yamanaka, Hiroki; Tsuge, Itaru; Arata, Jun; Sakamoto, Yuki; Kambe, Yusuke; Yamaoka, Tetsuji; Morimoto, Naoki

doi:10.1002/term.3041

Cited by 8 publications

(13 citation statements)

References 28 publications

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“…We developed an innovative method of breast reconstruction using a bioabsorbable implant that is substituted by newly formed adipose tissue after implantation without the use of growth factors or cells [ 36 , 37 ]. This implant aggregate consists of a poly- l -lactic acid (PLLA) mesh implant containing CS.…”

Section: Introductionmentioning

confidence: 99%

Preliminary report of de novo adipogenesis using novel bioabsorbable implants and image evaluation using a porcine model

et al. 2022

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Our bioabsorbable poly-l-lactic acid (PLLA) mesh implants containing collagen sponge are replaced with adipose tissue after implantation, and this is an innovative method for breast reconstruction. In this preliminary study, we investigated the formation of adipose tissue and evaluated the process via multimodal images in a porcine model using an implant aggregate to generate the larger adipose tissue. The implant aggregate consists of PLLA mesh implants containing collagen sponge and a poly-glycolic acid woven bag covering them. We inserted the implant aggregates under the porcine mammary glands. Magnetic resonance imaging (MRI), ultrasonography (USG), and 3-dimensional (3D) surface imaging and histological evaluations were performed to evaluate the formation of adipose tissue over time. The volume of the implant aggregate and the formed adipose tissue inside the implant aggregate could be evaluated over time via MRI. The space within the implant aggregate was not confirmed on USG due to the acoustic shadow of the PLLA threads. The change in volume was not confirmed precisely using 3D surface imaging. Histologically, the newly formed adipose tissue was confirmed on the skin side of the implant aggregate. This implant aggregate has the ability to regenerate adipose tissue, and MRI is an appropriate method for the evaluation of the volume of the implant aggregation and the formation of adipose tissue.

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Section: Introductionmentioning

confidence: 99%

Preliminary report of de novo adipogenesis using novel bioabsorbable implants and image evaluation using a porcine model

et al. 2022

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“…In phosphate-buffered saline at 37° C,PLLA was degraded to 50% by weight within two years and PGA was completely degraded within two to three months [25]. This implant needs to be lled with the formed adipose tissue inside at least one year [12,13]. Therefore, in the next experiment, we need to investigate the regeneration of adipose tissue over a year after implantation using ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanical force also affects adipogenesis, and an in vitro study reported that adipogenesis from ASCs is inhibited by mechanical compressive force [21] or mechanical stretch [22]. In our previous in vivo study, we reported the importance of maintaining the internal space for adipogenesis [12,13]. Large volumes of adipose tissue were regenerated via an autologous fat transfer using bioabsorbable, polycaprolactonebased scaffolds in a porcine model [23] and poly-4-hydroxybutyrate mesh scaffolds clinically [24].…”

Section: Discussionmentioning

confidence: 99%

“…We developed an innovative method of breast reconstruction using a bioabsorbable implant that is substituted by newly-formed adipose tissue after implantation without the use of growth factors or cells [12,13]. This implant aggregate consists of a poly-L-lactic acid (PLLA) mesh implant containing CS.…”

Section: Read Full License Introductionmentioning

confidence: 99%

“…The maintenance of the internal space in vivo for approximately one year after implantation is essential for the formation of adipose tissue using this PLLA implant in a rodent model [13]. However, the amounts of formed adipose tissue in rodent and rabbit models were not su cient to ll the volume required for breast augmentation following clinical mastectomy [12,13].…”

Section: Read Full License Introductionmentioning

confidence: 99%

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Preliminary Report of De Novo Adipogenesis Using Novel Bioabsorbable Implants and Image Evaluation Using A Porcine Model

Ogino

Yamada

Kambe

et al. 2021

Preprint

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Our bioabsorbable poly-L-lactic acid (PLLA) mesh implants containing collagen sponge is replaced with adipose tissue after implantation and is an innovative method for breast reconstruction. We investigated the formation of adipose tissue in a porcine model and evaluated the process via multimodal images in this preliminary study using an implant aggregate to generate the larger adipose tissue. The implant aggregate consists of PLLA mesh implants containing collagen sponge and a poly-glycolic acid woven bag covering them. We inserted the implant aggregates under the porcine mammary glands. Magnetic resonance imaging (MRI), ultrasonography (USG), and 3D surface imaging, and histological evaluations were performed to evaluate the formation of adipose tissue over time. The volume of the implant aggregate and the formed adipose tissue inside the implant aggregate could be evaluated over time via MRI. The space within the implant aggregate was not confirmed on USG due to the acoustic shadow of the PLLA threads. The change in volume was not confirmed precisely using 3D surface imaging. Histologically, the newly-formed adipose tissue was confirmed on the skin side. This implant aggregate has the ability to regenerate adipose tissue, and MRI is an appropriate method for the evaluation of the formation of adipose tissue.

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Development of new bioabsorbable implants with de novo adipogenesis

Zhao

Ogino

Lee

et al. 2023

Regenerative Therapy

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De novo adipogenesis using a bioabsorbable implant without additional cells or growth factors

Cited by 8 publications

References 28 publications

Preliminary report of de novo adipogenesis using novel bioabsorbable implants and image evaluation using a porcine model

Preliminary report of de novo adipogenesis using novel bioabsorbable implants and image evaluation using a porcine model

Preliminary Report of De Novo Adipogenesis Using Novel Bioabsorbable Implants and Image Evaluation Using A Porcine Model

Development of new bioabsorbable implants with de novo adipogenesis

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