De novo biosynthesis of juvenile hormone III and I by the accessory glands of the male mosquito

Borovsky, Dov; Carlson, David A.; Hancock, Robert G.; Rembold, Heinz; Handel, Emile Van

doi:10.1016/0965-1748(94)90038-8

Cited by 87 publications

(62 citation statements)

References 36 publications

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“…JH levels determine the competence of the ovaries and fat body to respond to blood feeding (15). The up-regulation of JH-responsive genes is consistent with the hypothesis that JH produced by the male accessory glands is transferred to the female during mating (16), and could also underlie the increased competence of mated females to produce mature eggs in response to a blood meal (4). The largest class of genes down-regulated at 6 h postmating comprised integral membrane transporters ( Fig.…”

Section: Resultssupporting

confidence: 63%

Molecular and cellular components of the mating machinery in Anopheles gambiae females

Rogers

Whitten

Thailayil

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

114

148

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Anopheles gambiae mosquitoes are the principal vectors of malaria. A major determinant of the capacity of these mosquitoes as disease vectors is their high reproductive rate. Reproduction depends on a single insemination, which profoundly changes the behavior and physiology of females. To identify factors and mechanisms relevant to the fertility of A. gambiae, we performed a comprehensive analysis of the molecular and cellular machinery associated with copulation in females. Initial whole-body microarray experiments comparing virgins with females at 2 h, 6 h, and 24 h after mating detected large transcriptional changes. Analysis of tissue localization identified a subset of genes whose expression was strikingly regulated by mating in the lower reproductive tract and, surprisingly, the gut. In the atrium of virgin females, where the male seminal fluid is received, our studies revealed a ''mating machinery'' consisting of molecular and structural components that are turned off or collapse after copulation, suggesting that this tissue loses its competence for further insemination. In the sperm storage organ, we detected a number of mating-responsive genes likely to have a role in the maintenance and function of stored sperm. These results identify genes and mechanisms regulating the reproductive biology of A. gambiae females, highlighting considerable differences with Drosophila melanogaster. Our data inform vector control strategies and reveal promising targets for the manipulation of fertility in field populations of these important disease vectors.mosquito ͉ post-mating response ͉ reproduction ͉ microarray ͉ reproductive tract

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Section: Resultssupporting

confidence: 63%

Molecular and cellular components of the mating machinery in Anopheles gambiae females

Rogers

Whitten

Thailayil

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

114

148

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“…Many Acps, which have been recently identified in Aedes males and mated females, are also suspected to influence female after mating (43). Additionally, JH, which is involved in ovarian follicle development to the pre-vitellogenic resting stage in female mosquitoes, is synthesized and stored in Aedes MAGs and possibly transferred to the female during mating (44). In Anopheles, mating-induced changes in female mediated by MAG secretions have also been demonstrated (45,46), but the mediators remained uncharacterized.…”

Section: Discussionmentioning

confidence: 99%

Anopheles gambiaemales produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating

Pondeville

Maria

Jacques

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

109

127

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In female insects, the steroid hormone 20-hydroxyecdysone (20E) plays a major role in activating vitellogenesis, a process required for egg development. By contrast with vertebrates, production of large amounts of hormonal steroids has not been reported in adult male insects. In the present study, we analyzed steroidogenesis in both male and female adult of the malaria mosquito Anopheles gambiae and we found that A. gambiae male mosquitoes produce high amounts of the steroid hormone 20E. Importantly, we found that male accessory glands, but not testes, are the source of 20E. Moreover, this steroid hormone is stored in male accessory glands and delivered to females during mating. These findings suggest that male 20E may not act as a true male sex steroid, but more likely as an allohormone. Our results give new insights into speciesspecific physiological processes that govern the reproductive success of the malaria mosquito. This could thus lead to the identification of new target genes for manipulating male and/or female reproductive success, a promising way to reduce or eliminate mosquito population and therefore to control malaria transmission.allohormone ͉ ecdysteroids ͉ malaria ͉ male accessory glands ͉ mosquito

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“…In addition, they may contain a variety of other biologically active components, such as prostaglandins in Lepidoptera (Gillott, 1988), juvenile hormone (JH) in the moth Hyalophora cecropia (Shirk et al, 1980) and possibly also in some mosquitoes (Borovsky et al, 1994), and toxic compounds that have been suggested to serve as egg protectants (Blum and Hilker, 2002;Eisner et al, 2002).…”

Section: Male Accessory Gland (Mag) Products and Their Function In Inmentioning

confidence: 99%

She’s my girl - male accessory gland products and their function in the reproductive biology of social bees

Colonello-Frattini

Hartfelder

2005

Apidologie

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-Male accessory gland products have become a major issue in insect reproduction. They are a means of transport for sperm and can form a mating plug, and also have specific compounds that can modify the behavior and physiology of mated females. We briefly review the structure and function of accessory gland products in insects, especially in the fruitfly and some orthopterans and lepidopterans, and draw parallels to what is currently known in social bees. The structure of the mating sign differs considerably in this group. In bumble bees it consists of a viscous mass of a dipeptide and fatty acids, with linoleic acid affecting female behavior. The honey bees show considerable species-specific variation in their mating signs. In the cavity-dwelling species it is the mucus gland which provides the mass of the mating sign, and this glands undergoes a hormonally controlled sexual maturation in its program of protein synthesis. The stingless bees lack mucus glands altogether, and their mating sign consists of the ruptured genital capsule of the male. We discuss the structure of the mating sign and of its components in relation to the mating and reproductive biology of these groups of highly eusocial bees.honeybee / bumblebee / Meliponini / reproductive tract / mating sign / Apis / Bombus

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De novo biosynthesis of juvenile hormone III and I by the accessory glands of the male mosquito

Cited by 87 publications

References 36 publications

Molecular and cellular components of the mating machinery in Anopheles gambiae females

Molecular and cellular components of the mating machinery in Anopheles gambiae females

Anopheles gambiaemales produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating

She’s my girl - male accessory gland products and their function in the reproductive biology of social bees

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