De novo development of presumed cavernomas following resolution of E. Coli subdural empyemas

Fender, Laura; Lenthall, Robert; Jaspan, Tim

doi:10.1007/s002340000397

Cited by 17 publications

(4 citation statements)

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“…2 Furthermore, major bleeding may occur both extra-and intralesionally: the risk of overt hemorrhage in CMs depends on the patient's age and sex and on factors related to the lesion (location, associated venous malformation, previous bleeding). 10 In addition, environmental factors (radiation therapy, infection, and hormone therapy) 4,6,11 may interfere with the biological behavior of CMs.…”

Section: Discussionmentioning

confidence: 99%

Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy

Pozzati¹,

Zucchelli²,

Marliani³

et al. 2006

FOC

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✓The risk of hemorrhage in cavernous malformations (CMs) depends on lesion, host, and environmental factors. Anticoagulation therapy is a well-known risk factor for intracerebral bleeding, but the occurrence of hemorrhages in patients with CMs has not been reported. Low molecular weight heparin therapy is generally considered to be safe, although significant hemorrhagic complications have recently been reported. The authors report a case of intralesional bleeding in a CM after prophylactic anticoagulation therapy was administered in a patient with the familial form of the disease. The leaky endothelial structure of CMs may constitute an unexpected target of the vascular effects of heparin.

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Section: Discussionmentioning

confidence: 99%

Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy

Pozzati¹,

Zucchelli²,

Marliani³

et al. 2006

FOC

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“…15,19) Furthermore, environmental factors including irradiation and infection may interfere with the biological behavior of cavernomas. 5,16) Simultaneous hemorrhages from distinct lesions in this case may be predisposed by extralesional mechanisms such as hormone expression.…”

Section: Discussionmentioning

confidence: 82%

"Kissing" Brainstem Cavernous Angiomas Removed Using a Trans-Fourth Ventricular Floor Approach -Case Report-

Murata

Horiuchi

Hanaoka

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 39-year-old woman presented with a rare case of``kissing'' brainstem cavernomas formed by separate lesions enlarging with simultaneous recurrent hemorrhages, which was successfully treated by staged resection using a trans-fourth ventricular floor approach. She had a familial history of cerebral cavernous angioma, and presented with a history of four episodes of sudden neurological deterioration. Magnetic resonance (MR) imaging obtained at each neurological event demonstrated two distinct brainstem cavernomas located in the pontine tegmentum and ventral part of the lower pons, both of which enlarged stepwise caused by simultaneous recurrent hemorrhages. Both cavernomas contacted and formed``kissing'' lesions. She underwent midline suboccipital craniotomy in the prone position. The cavernoma in the pontine tegmentum was resected through a trans-fourth ventricular floor approach. Although``kissing'' formation appeared on preoperative MR imaging, parenchyma was identified at the bottom of the removal cavity of the dorsal lesion, and resection was terminated. MR imaging following the first surgery revealed complete resection of the pontine tegmentum cavernoma and the ventral pontine cavernoma, which was located adjacent to the bottom of the removal cavity and aligned in same direction along the fourth ventricular floor approach. At 10 days after first surgery, she underwent the same procedure with the aid of neuronavigation to resect the ventral pontine cavernoma through the former removal cavity. This approach through the previous removal route, particularly for resection of`k issing'' lesions which are difficult to access in the brainstem, is a technically feasible microsurgical procedure.

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“…CM is also observed in patients with cerebromeningitis. Thus, the external factors may have effects on CM genesis [15,16] . This investigation is the first time to isolate successfully the endothelial cells from CM tissue removed the patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of vascular endothelial growth factor on angiogenesis of the endothelial cells isolated from cavernous malformations

et al. 2008

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Human cerebral cavernous malformation (CM) is a common vascular malformation of the central nervous system. We have investigated the biological characteristics of CM endothelial cells and the cellular and molecular mechanisms of CM angiogenesis to offer new insights into exploring effective measures for treatment of this disease. The endothelial cells were isolated from CM tissue masses dissected during operation and expanded in vitro. Expression of VEGFR-1 and VEGFR-2 was examined with immunocytochemical staining. Proliferation, migration and tube formation of CM endothelial cells were determined using MTT, wounding and transmigration assays, and three-dimensional collagen type I gel respectively. The endothelial cells were successfully isolated from the tissue specimens of 25 CMs dissected without dipolar electrocoagulation. The cells show the general characteristics of the vascular endothelial cells. Expression of VEGFR-1 and VEGFR-2 on the cells is higher than that on the normal cerebral microvascular endothelial cells.After treatment with VEGF, numbers of the proliferated and migrated cells, the maximal distance of cell migration and the length and area of capillary-like structures formed in the three-dimensional collagen gel increase significantly. These results demonstrate that expression of VEGFR-1 and VEGFR-2 on CM endothelial cells is up-regulated.

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De novo development of presumed cavernomas following resolution of E. Coli subdural empyemas

Cited by 17 publications

References 0 publications

Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy

Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy

"Kissing" Brainstem Cavernous Angiomas Removed Using a Trans-Fourth Ventricular Floor Approach -Case Report-

Effects of vascular endothelial growth factor on angiogenesis of the endothelial cells isolated from cavernous malformations

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