De Novo Extramedullary Plasmacytoma of Thyroid Cartilage

Gupta, Manoj; Pasricha, Sunil; Ahmed, Rayaz; Khoda, Jeevitesh; Choudhury, Partha Sarathi

doi:10.1097/rlu.0000000000004403

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Plasma cell myeloma patients may display atypical myelomatous presentation. [1][2][3][4][5][6][7] Previous challenging cases with hematologic and solid malignancies were reported with hepatic superscan, [8][9][10][11] but no cases of coexisting hepatosplenic superscan in hematologic malignancies have been documented. Cartilaginous involvement has been reported in relapsed and progressive myelomatous disease, 2,12 but the detection of potential involvement during staging has never been documented, as far as our knowledge extends.…”

Section: Figurementioning

confidence: 99%

“…Tragically, the patient’s clinical state rapidly deteriorated due to multiorgan failure, leading to death 26 days following admission. Plasma cell myeloma patients may display atypical myelomatous presentation 1–7 . Previous challenging cases with hematologic and solid malignancies were reported with hepatic superscan, 8–11 but no cases of coexisting hepatosplenic superscan in hematologic malignancies have been documented.…”

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confidence: 99%

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18F-FDG PET/CT Unveils Coexistent Myelomatous Hepatosplenic and Thyroid Cartilage Involvement

Abdlkadir,

Almasri,

Estrada

et al. 2024

Clin Nucl Med

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Extramedullary myelomatous disease is an aggressive condition where clonal plasma cells proliferate outside the bone marrow, allowing independent survival. This state is generally associated with negative outcomes. A 65-year-old woman presented with progressive bilateral hypochondrial pain, was initially misattributed to an inflammatory etiology, and was consequently managed with corticosteroid therapy. A bone marrow biopsy was offered after further deterioration confirming plasma cell myeloma. Afterward, 18F-FDG PET/CT revealed medullary and extramedullary hepatosplenic and thyroid cartilage involvement, concluding an overall picture of an atypical and extensive extramedullary myelomatous disease.

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Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

18F-FDG PET/CT Unveils Coexistent Myelomatous Hepatosplenic and Thyroid Cartilage Involvement

Abdlkadir,

Almasri,

Estrada

et al. 2024

Clin Nucl Med

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show abstract

“…The most frequent site of extramedullary plasmacytoma is the upper airways 3 . Extramedullary plasmacytoma involving the thyroid, 4 thyroid cartilage, 5 nasal cavity, 6 and lung 7 has been reported. However, extramedullary plasmacytoma in the anterior mediastinum was rarely reported 8 .…”

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confidence: 99%

FDG PET/CT Image of Extramedullary Plasmacytoma in the Anterior Mediastinum

Xiao,

2023

Clin Nucl Med

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Extramedullary plasmacytoma in the anterior mediastinum is very rare. We report FDG PET/CT findings of anterior mediastinum extramedullary plasmacytoma in a 54-year-old woman. On FDG PET/CT, it presented as a solitary anterior mediastinum mass with increased FDG uptake. The final pathology supported a diagnosis of extramedullary plasmacytoma. This case hints us that extramedullary plasmacytoma should be regarded as a differential diagnosis when we encounter a solitary anterior mediastinum mass with intense FDG uptake.

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Skeletal muscle extramedullary plasmacytoma transformed into plasmablastic plasmacytoma: a case report

Zhang,

Zhi,

Yang

et al. 2024

J Cancer Res Clin Oncol

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Background Extramedullary plasmacytoma (EMP) is a rare plasma cell malignancy, especially when the tumor originates in skeletal muscle. Plasmablastic plasmacytoma is an anaplastic round cell tumor with highly malignancy and poor prognosis. To date, there have been no reports on the transformation of skeletal muscle EMP into plasmablastic plasmacytoma. Therefore, the diagnosis, treatment, and prognosis of cases of this pathologic transformation are unclear. Case presentation This article reports a case of an elderly male patient who presented with a painless mass in the right calf and was diagnosed with EMP by puncture pathology. Complete remission was obtained after sequential chemoradiotherapy. 6 months later, another puncture was performed due to plasmablastic plasmacytoma multiple distant metastases, and the pathology showed that EMP was transformed to plasmablastic plasmacytoma. Despite aggressive antitumor therapy, the disease continued to deteriorate, and the patient ultimately died of respiratory failure. Conclusion The transformation of EMP into plasmablastic plasmacytoma is very rare, and its diagnosis and treatment require the participation of both experienced pathologists and clinicians. We report this case in order to raise clinicians' awareness of the diagnosis and treatment of EMP and its transformation to plasmablastic plasmacytoma, and to avoid misdiagnosis and underdiagnosis.

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De Novo Extramedullary Plasmacytoma of Thyroid Cartilage

Cited by 5 publications

References 22 publications

18F-FDG PET/CT Unveils Coexistent Myelomatous Hepatosplenic and Thyroid Cartilage Involvement

18F-FDG PET/CT Unveils Coexistent Myelomatous Hepatosplenic and Thyroid Cartilage Involvement

FDG PET/CT Image of Extramedullary Plasmacytoma in the Anterior Mediastinum

Skeletal muscle extramedullary plasmacytoma transformed into plasmablastic plasmacytoma: a case report

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