De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation

Bilginer, Burçak; Türk, Cezmi Çağrı; Narin, Fırat; Hazer, Derya Burcu; Hanalıoğlu, Şahin; Oğuz, Kader K.; Söylemezoğlu, Figen; Akalan, Nejat

doi:10.1007/s00381-015-2689-3

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…The 3 years progression-free survival rate ranges from 0 to 8.7% [15,16]. Although radiotherapy and chemotherapy are considered as significant risk factors for secondary cancer, current findings do not support radiotherapy or chemotherapy withdrawal based on risk of future second tumors, since recent publications reported about a quite low rate of second brain cancer in patients treated with radiochemotherapy (0.08-1.25%) [17,18].…”

Section: Discussioncontrasting

confidence: 55%

A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas

et al. 2016

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Malignant meningioma has a bad prognosis. Surgery and radiotherapy are the most effective therapeutic options, without an established role for chemotherapy. We report a case of 2-year-old male child with diagnosis of postoperative relapse of a malignant meningioma. Considering the rapid progression, the young age and the lack of effective therapeutic alternatives, the patient underwent multidisciplinary anticancer treatment with a protocol made for soft tissue sarcomas (EpSSG NRSSTS 2005 protocol), with positive outcome. This case represents a successful management of an anaplastic meningioma with a multimodal treatment, including chemotherapy, in a pediatric patient.

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Section: Discussioncontrasting

confidence: 55%

A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas

et al. 2016

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“…Formation of secondary tumor (other than the primary tumor type) was discussed in the literature before. We have published our experience regarding second primary tumors (6). Our retrospective analysis revealed that there were 2 high-grade glial tumors arising after 6 and 11 years after radiotherapy.…”

Section: █ Discussionmentioning

confidence: 99%

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

Bilginer¹,

Hanalıoğlu²,

Türk³

et al. 2015

Turkish Neurosurgery

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There is a paucity of information in the literature about agespecific histopathological and molecular biology. This is also true for prognostic factors and therapeutic strategies regarding pediatric glioblastoma. The current understanding is therefore majorly based on adult data.The incidence and spectrum of pediatric CNS tumors have been addressed in several studies in the literature. Despite geographical differences, the incidence of glioblastoma was updated to 7-12 % of all pediatric brain tumors (12,30). (8,21). This predominance is responsible for the general perception regarding GBM as a "tumor of the elderly". Indeed, pediatric cases are rare, accounting for 3-6 % of all glioblastomas. The incidence may be responsible for the underestimation of this devastating pathology in childhood.AIM: Pediatric glioblastoma (GBM) is still a topic obscurity. The aim of this study was to explore clinical, radiological and pathological features, and prognostic factors affecting the outcomes. MATERIAL and METhODS:We retrospectively reviewed our database for prognostic factors for 42 consecutive pediatric patients with histologically proven GBM treated in our hospital. RESuLTS:The study reached at 20 boys and 22 girls, with a mean age of 10.2 years. Almost all patients (97.6%) had supratentorial tumors; lobar/hemispheric (68.3%), thalamic (26.8%) and suprasellar-hypothalamic region (4.8%). Total of 11/42 children had seeding metastases (mean 11.5 months) either preoperatively or postoperatively. Gross total resection (GTR) was achieved in 13 patients (30.9%) in the first surgery. Perioperative mortality and morbidity rates were 4.7% and 19%, respectively. Patients were followed for an average of 18.1 months. The median progression-free and overall survivals were 7.0 (95% CI: 5.9-8.0) and 11.0 (95% CI: 8.9-13.1) months, respectively. 1-year, 2-year and 5-year progression-free survival and overall survivals were 30.9% vs. 50.0%, 11.9% vs. 19.0%, 4.8% vs. 9.5%; respectively.COnCLuSIOn: Gross total resection should be safely attempted in pediatric GBM. In addition, a thorough and frequent radiological evaluation of the entire neuraxis for seeding metastases is recommended both at diagnosis and follow-ups.

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“…There is a recommendation that secondary brain tumour screening by MRI should be performed annually for the initial 5 years after completion of the radiotherapy, and thereafter repeated MRI screening should be performed only for the patients with neurological symptoms, such as headache, cognitive changes and seizures, particularly in those with a history of haematological malignancy or radiotherapy at a young age [ 44 ]. However, large sample, prospective randomised studies are needed in this regard.…”

Section: Post-remission Phasementioning

confidence: 99%

MR imaging findings in some rare neurological complications of paediatric cancer

et al. 2018

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Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Neurological complications are classified into three phases: pre-treatment, treatment and post-remission. Paraneoplastic neurological syndromes, hyperviscosity syndrome, haemophagocytic lymphohistiocytosis and infection are found in the pre-treatment phase, while Trousseau’s syndrome, posterior reversible encephalopathy syndrome and methotrexate neurotoxicity are found in the treatment phase; though some complications overlap between the pre-treatment and treatment phases. Hippocampal sclerosis, radiation induced tumour, radiation induced focal haemosiderin deposition and radiation-induced white matter injury are found in the post-remission phase. With increasingly long survival after treatment, CNS complications have become more common. It is critical for radiologists to recognise neurological complications related to paediatric cancer or treatment. Magnetic resonance imaging (MRI) plays a significant role in the recognition and proper management of the neurological complications of paediatric cancer.Teaching Points• Neurological complications of paediatric cancer include various entities.• Neurological complications are classified into three phases: pre-treatment, treatment and post-remission.• Radiologists should be familiar with clinical and imaging findings of neurological complications.• MRI features may be characteristic and lead to early diagnosis and proper treatments.

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De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation

Abstract: de novo brain tumors after irradiation has poor prognosis in neurosurgical practice. Vigilance and awareness for possibility of de novo new tumor are warranted for both families and physicians at follow-ups even years after the treatment of initial tumors.

Cited by 7 publications

References 21 publications

A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas

A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

MR imaging findings in some rare neurological complications of paediatric cancer

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