De novo lipogenesis in metabolic homeostasis: More friend than foe?

Solinas, Giovanni; Borén, Jan; Dulloo, Abdul G.

doi:10.1016/j.molmet.2015.03.004

Cited by 159 publications

(121 citation statements)

References 106 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…DNL has been proposed as a pathway for sustaining metabolic homeostasis, and although an energetically inefficient way to store excess energy, it is an important mechanism for glucose disposal (36). Despite subjects consuming two test meals, we did not observe a marked divergence in postprandial hepatic DNL between the groups.…”

Section: Discussioncontrasting

confidence: 57%

Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults

et al. 2016

View full text Add to dashboard Cite

Resistance to the action of insulin affects fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver, and triglyceride export from the liver. To understand the metabolic consequences of hepatic fatty acid synthesis, partitioning, oxidation, and net liver fat content in the fasted and postprandial states, we used stable-isotope tracer methodologies to study healthy men and women with varying degrees of insulin resistance before and after consumption of a mixed meal. Subjects were classified as being normoinsulinemic (NI) (fasting plasma insulin <11.2 mU/L, n = 18) or hyperinsulinemic (HI) (fasting plasma insulin >11.2 mU/L, n = 19). Liver fat content was similar between HI and NI individuals, despite HI subjects having marginally more visceral fat. However, de novo lipogenesis was higher and fatty acid oxidation was lower in HI individuals compared with NI subjects. These data suggest that metabolic pathways promoting fat accumulation are enhanced in HI but, paradoxically, without any significant effect on liver fat content when observed in healthy people. This is likely to be explained by increased triglyceride secretion as observed by hypertriglyceridemia.

show abstract

Section: Discussioncontrasting

confidence: 57%

Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Hepatic DNL is positively correlated with insulin resistance and a fatty liver, but adipose tissue DNL is negatively correlated with these 2 factors [12,28] . Therefore, the serum NAMPT level might have a different prognosis for each sex and the contrary findings for the association between serum NAMPT and pathologic findings of NAFLD [29] could be partly due to the sex distribution in various studies.…”

Section: Discussionmentioning

confidence: 97%

“…Recent studies indicate that hepatic DNL and adipose tissue DNL are 2 pathways that support metabolic homeostasis and when one decreases the other increases to sustain blood glucose homeostasis [12,24] . In this study, it could be speculated that higher serum NAMPT in women might also be associated with a higher adipose tissue DNL.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicated that DNL has different effects on the progression of NAFLD depending its source (liver or adipose tissue). Hepatic DNL causes a fatty liver and insulin resistance while adipose tissue DNL is negatively correlated with these factors [12] . It is important to determine which source of DNL correlates more closely with serum NAMPT.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease

Amirkalali

Sohrabi²,

Esrafily³

et al. 2017

Med Princ Pract

View full text Add to dashboard Cite

Objective: This study explored the association between serum nicotinamide phosphoribosyltransferase (NAMPT) and hepatic de novo lipogenesis (DNL) in nonalcoholic fatty liver disease (NAFLD) and determined whether or not this association is sex dependent. Subjects and Methods: In this cross-sectional study, 62 consecutive patients (32 males, 30 females) with NAFLD were recruited. Serum NAMPT (by ELISA), palmitic acid, and the DNL index of erythrocyte membranes as markers of hepatic DNL (by gas chromatography) were analyzed. The controlled attenuation parameter (CAP) and body impedance analyzer were used to assess hepatic and body fat, respectively. Univariate and multiple linear regressions (to adjust for confounders) were used to analyze the association of serum NAMPT with palmitic acid, DNL index, CAP, and body fat. Results: The respective values of serum NAMPT (2.44 ± 1.03 vs. 2.45 ± 1.13 ng/mL, p = 0.98), DNL index (3.11 [2.60-3.71] vs. 3.05 [2.40-3.59], p = 0.90), and palmitic acid (20.55% [15.34-24.04] vs. 22.64% [21.15-25.95], p = 0.07) were not significantly different between men and women, but those of CAP (326 [300-340] vs. 300 [261.25-329], p = 0.002) and body fat (37.71 ± 3.80 vs. 26.60 ± 5.70, p < 0.001) were significantly higher in women. In women, serum NAMPT had a significant negative association with the DNL index (β = -0.56, p = 0.01). The DNL index also had a significant negative association with body fat (β = -0.46, p = 0.02). In men, the only significant association was the positive association between serum NAMPT and CAP (β = 0.35, p = 0.035). Conclusion: Higher serum NAMPT in women was associated with a lower hepatic DNL index, while in men it was associated with higher hepatic fat and had no association with the DNL index. Therefore, the serum NAMPT level interpretation for NAFLD prognosis is probably sex dependent.

show abstract

“…Hepatic DNL is positively correlated yet adipose tissue DNL is negatively correlated with fatty liver (31,32). Based on this knowledge, it is logical that serum visfatin level and markers of hepatic injury have no significant associations, where serum visfatin level is more associated with its level in adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Interpretation of Serum Visfatin Level in Relation to Hepatic Injury is Probably Gender Dependent in Nonalcoholic Fatty Liver Disease

et al. 2017

View full text Add to dashboard Cite

Background: Studies on the association between visfatin and nonalcoholic fatty liver disease (NAFLD) have contradictory results and the role of this adipokine in NAFLD pathogenesis has remained unclear. In vitro studies indicate that visfatin expression could be regulated by sex hormones. Testosterone down-regulates visfatin expression in pre-adipocytes and estrogen increases its expression in adipocytes. Objectives: This study aimed at exploring whether the association between serum visfatin and markers of hepatic injury is the same for both genders in patients with NAFLD. Methods: In this cross-sectional study, 62 consecutive patients (32 males and 30 females) with NAFLD were recruited. Fasting serum visfatin, caspase-cleaved cytokeratin 18 (cCK18), total soluble cytokeratin 18 (CK18), liver enzymes (AST and ALT), insulin, and lipidglucose profile was measured. Anthropometric measurements, fibroscan and assessment of dietary intake and physical activity level, were performed for each participant. Two independent sample t tests, chi-square test, univariate, and multiple linear regression (to adjust for confounding factors) were used to analyze the data. Results: In males, serum visfatin had a significant positive association with serum Aspartate Aminotransferase (AST) (B = 0.47, P = 0.009), alanine aminotransferase (ALT) (B = 0.40, P = 0.035), CK18 (B = 0.50, P = 0.008), and cCK18 (B = 0.47, P = 0.012). In females, serum visfatin only had a weak association with CK18 (B = 0.37, P = 0.045). Instead, higher body mass index (BMI) was significantly associated with increased serum CK18 (B = 0.44, P = 0.02), cCK18 (B = 0.42, P = 0.02), controlled attenuation parameter (CAP) (B = 0.39, P = 0.049), and liver stiffness measurement (LSM) (B = 0.40, P = 0.03) in females. Higher waist to hip ratio was also significantly related to serum AST (B = 0.37, P = 0.04), ALT (B = 0.50, P = 0.02), CK18 (B = 0.41, P = 0.03), cCK18 (B = 0.37, P = 0.04), and CAP (B = 0.39,

show abstract

De novo lipogenesis in metabolic homeostasis: More friend than foe?

Cited by 159 publications

References 106 publications

Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults

Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults

Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease

Interpretation of Serum Visfatin Level in Relation to Hepatic Injury is Probably Gender Dependent in Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About