De Novo Lower Urinary Tract Symptoms in COVID-19 Patients

Jain, Saurabh; Kothari, Akanksha; Pipal, Dharmendra Kumar; Saxena, Sharad; Yadav, Seema; Tomar, Vinay; Kumar, Mukteshwar; Bhargava, Anupam; Usmani, Amir; Soni, Amit

doi:10.7759/cureus.33947

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Enrichment analysis in DisGeNET also highlighted delayed myelination, which is commonly caused by viral infections 43 . Whilst looking at the enrichment according to fold-changes, we found Immune system process and Localization to be the top-level gene ontology biological processes, and an enrichment for infective cystitis, which has been reported to occur in some COVID-19 patients 46 . Further enrichment analysis in TRRUST 44 indicated the top predicted biological processes for T2 versus HCs, as Multicellular organismal process and Negative regulation of biological process (adjusted p value), and an enrichment of the regulation by the tumor suppressor gene TP53.…”

Section: Resultsmentioning

confidence: 92%

Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patients

Govender,

Das,

Hopkins

et al. 2024

Preprint

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The emergence of SARS-CoV-2 has had a profound adverse impact on global health and continues to remain a threat worldwide. The disease spectrum of COVID-19 ranges from asymptomatic to fatal clinical outcomes especially in the elderly population and in individuals with underlying medical conditions. The impact of COVID-19 on host immune responses and immune cells at the protein and DNA levels remains largely ambiguous. In a case-control study, here we explored the impact of COVID-19 on DNA methylation patterns in the upper respiratory airway to determine how SARS-CoV-2 infection altered the immune status of individuals requiring hospitalization for COVID-19. We performed DNA methylation arrays on nasopharyngeal swabs at inclusion/hospitalization as well as 6 weeks post-inclusion. Our study reveals a distinct DNA methylation pattern in COVID-19 patients compared to healthy controls, characterized by 317 779 differentially methylated CpGs. Notably, within the transcription start sites and gene body, COVID-19 patients exhibited a higher number of genes/CpGs with elevated methylation levels. Enrichment analysis of methylated genes at transcription start sites highlighted the impact on genes associated with inflammatory responses and immune functions. Some SARS-CoV-2 -induced CpG methylations were transient, returning to normal levels by 6 weeks post-inclusion. Enriched genes of interest included IL-17A, a pivotal cytokine implicated with inflammation and healing, and NUP93, associated with antiviral innate immunity. Further, six genes in our data set, OAS1, CXCR5, APP, CCL20, CNR2, and C3AR1, were found in enrichment analysis with previous COVID-19 studies. Additionally, RNAse1 and RNAse2 emerged as key regulators, while IL-18 played a role in various biological processes in COVID-19 patients. Overall, our results demonstrates that COVID-19 has a major impact on the upper airway by modifying the methylation pattern of many genes and this could have implications for the conditioning of the airways and how the individual response to future airway infections.

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Section: Resultsmentioning

confidence: 92%

Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patients

Govender,

Das,

Hopkins

et al. 2024

Preprint

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“…The ICIQ-UI SF, with an intraclass correlation coefficient of 0.73 and a Cronbach's alpha of 0.87, consists of four questions and provides a score ranging from 0 to 21, where a higher score indicates more severe symptoms. This questionnaire categorizes urinary incontinence severity into four levels: slight (1-5), moderate (6)(7)(8)(9)(10)(11)(12), severe (13)(14)(15)(16)(17)(18), and very severe (19)(20)(21). On the other hand, the ICIQ-MLUTS, comprising 13 items, is designed to evaluate voiding and storage symptoms along with their impact on the patient's life.…”

Section: Methodsmentioning

confidence: 99%

“…Emerging evidence indicates that COVID-19 can affect the urinary system, with post-COVID males experiencing UI, significantly impacting their QoL [13]. The exact mechanisms linking COVID-19 to UI remain unclear, but potential factors include direct viral effects on the urinary system, COVID-19-related hospitalization, immobility, and specific medication uses [14,15].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Urinary Incontinence Among Post COVID Males

Farooq,

Faisal,

Rashid

et al. 2023

JHRR

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Background: Amid the global health challenges posed by the COVID-19 pandemic, an association with urinary system complications has been identified. Urinary incontinence (UI) has become a significant post-COVID sequela among males, with substantial implications for their quality of life. Objective: The study aimed to quantify the frequency and delineate the severity of urinary incontinence in post-COVID male patients, as well as to document the prevalence of associated lower urinary tract symptoms. Methods: A cross-sectional observational study was executed, engaging 400 male post-COVID patients aged between 45 to 64 years from three hospitals in Lahore. Participants were selected via non-probability convenience sampling and provided data through the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) and Male Lower Urinary Tract Symptoms (ICIQ-MLUTS). Statistical analyses were performed using SPSS version 21. Results: The prevalence of urinary incontinence among the participants was high, with 367 (91.75%) reporting some degree of UI. In terms of severity, moderate UI was the most common, affecting 248 (67.5%) of those with UI, followed by slight UI in 82 (22.5%), and severe UI in 37 (10%) participants. The study identified urgency (reported by 133 participants or 33.3% 'occasionally' and 132 or 33% 'most of the time') and postvoid dribbling (reported by 159 participants or 39.8% 'most of the time') as the most frequent symptoms. Notably, there were no reports of very severe urinary incontinence. Conclusion: The study concludes a high prevalence of urinary incontinence among male patients post-COVID-19, with the majority experiencing moderate severity. These findings underscore the importance of including urinary incontinence assessments in post-COVID patient care and may inform the development of targeted interventions to improve patient outcomes.

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