De Novo Secondary Adenocarcinoma in the Colon Used as Urinary Diversion Not in Contact with the Fecal Stream: Systematic Review and Meta-analysis

Sterpetti, Antonio V.; U, Costi; Grande, Raffaele; D'Ermo, Giuseppe; Sapienza, Paolo

doi:10.1245/s10434-020-08300-4

Cited by 4 publications

(4 citation statements)

References 52 publications

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“…Contact between the colonic mucosa and urine is a known risk factor for malignant transformation. 10 However, there is evidence that the Yang–Monti technique may not be associated with malignant transformation in the colon 7 and in reports of malignant transformation most patients were older than 50 years. 9 While malignant transformation can be symptomatic with fever of unknown origin, localized discomfort, or abnormal serum biochemistry, routine screening with cystoscopy/colonoscopy every 5 to 10 years or CT colonography every 5 years for patients ≥50 years with GIT segment tissue interposition is recommended.…”

Section: Discussionmentioning

confidence: 99%

“…Contact between colonic mucosa and urine is a known risk factor for malignant transformation 10 . However, there is evidence that the Yang-Monti technique may not be associated with malignant transformation in colon 7 and in reports of malignant transformation most patients were over 50 years old 9 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…However, there is evidence that the Yang-Monti technique may not be associated with malignant transformation in colon 7 and in reports of malignant transformation most patients were over 50 years old 9 . While malignant transformation can be symptomatic with fever of unknown origin, localized discomfort, or abnormal serum biochemistry, routine screening with cystoscopy/colonoscopy every 5 to 10 years or CT colonography every 5 years for patients 50 or more years old with GIT segment tissue interposition is recommended 10,11 . For the present case, magnetic resonance imaging may be more appropriate for investigating hematuria or hydronephrosis identified on follow-up US, because it is non-invasive.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Upper Ureteral Reconstruction with a Tapered Descending Colon after Failed Pyeloplasties in a 13-Year-Old Boy

Nakajima

Koga

Kosaka

et al. 2023

European J Pediatr Surg Rep.

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An 11-year-old boy was referred for further management of a 6cm long grossly stenosed ureter following two failed left ureteropelvic junction (UPJ) obstruction repairs, elsewhere. A tapered segment of descending colon (TDC) was used successfully for ureteral reconstruction. The UPJ was exposed through a left flank incision. The stenosed segment was excised; both ends appeared severely inflamed and thickened. Tissue interposition was required and ureteroplasty with TDC was performed by incising the peritoneum adjacent to the excised ureter to mobilize the descending colon to the retroperitoneal space. To prepare the TDC, an 8cm segment of colon with intact blood vessels was isolated, tapered, and sutured into a funnel-shape using a 14Fr catheter as a temporary stent. After colocolostomy, the colon was returned to the abdominal cavity, the peritoneum was closed carefully to prevent vascular compromise, and the TDC was anastomosed to the ureter and renal calyx with interrupted absorbable sutures. A double J stent (DJS), and percutaneous nephrostomy tube were placed. Postoperative recovery was uneventful. The DJS was removed on day 50 after confirming smooth urine flow through both the ureter-TDC and calyx-TDC anastomoses. Diuretic renography performed 68 days postoperatively, was unobstructed. The patient is currently well after 12 months follow-up. This would appear to be the first report of TDC being used to create a funnel-shaped segment to reconstruct a long, grossly stenosed ureter. TDC is simpler than retubularizing colon but requires monitoring for postoperative mucus-related complications and malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Upper Ureteral Reconstruction with a Tapered Descending Colon after Failed Pyeloplasties in a 13-Year-Old Boy

Nakajima

Koga

Kosaka

et al. 2023

European J Pediatr Surg Rep.

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“…Colorectal cancer (CRC), which is one of the most diagnosed malignancies, is a leading cause for cancer-related mortality worldwide. 1 Although the therapeutic approaches for colon cancer have been improved, the overall 5-year survival rate of CRC patients is still under that expected. 2 5-Fluorouracil (5-Fu), which has been applied for CRC therapy for more than four decades, is a palliative and adjuvant anti-cancer agent by interfering with the nucleotide synthesis of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis

Gao

Ren

Liu

et al. 2021

Molecular Therapy - Oncolytics

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5-Fluorouracil (5-Fu) is a widely applied anti-cancer agent against colorectal cancer (CRC), yet a number of CRC patients have developed resistance to 5-Fu-based chemotherapy. The epidermal growth factor receptor (EGFR) is recognized as an oncogene that promotes diverse cancer progresses. In addition, long noncoding RNAs (lncRNAs) are essential regulators of cancers. Here we report that EGFR and lncRNA-FGD5-AS1 promoted 5-Fu resistance of CRC. By establishing the 5-Fu-resistant CRC cell line, we detected that EGFR, FGD5-AS1, and glucose metabolism were significantly elevated in 5-Fu-resistant CRC cells. A microRNA-microarray analysis revealed that miR-330-3p functions as a downstream effector of FGD5-AS1. FGD5-AS1 directly sponged miR-330-3p to form a competing endogenous RNA (ceRNA) network, leading to inhibition of miR-330-3p expression. Furthermore, bioinformatics analysis revealed that Hexokinase 2 (HK2) was a potential target of miR-330-3p, which was validated by luciferase assay. Rescue experiments demonstrated that FGD5-AS1 promotes glycolysis through modulating the miR-330-3p-HK2 axis, leading to 5-Fu resistance of CRC cancer cells. Finally, in vitro and in vivo xenograft experiments consistently demonstrated that inhibition of EGFR by the specific inhibitor erlotinib effectively enhanced the anti-tumor toxicity of 5-Fu by targeting the EGFR-FGD5-AS1-miR-330-3p-HK2 pathway. In summary, this study demonstrates new mechanisms of the EGFR-modulated 5-Fu resistance through modulating the noncoding RNA network, contributing to development of new approaches against chemoresistant CRC.

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Long-term risks of childhood surgery

Win

Kort

Learner

et al. 2024

Journal of Pediatric Urology

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De Novo Secondary Adenocarcinoma in the Colon Used as Urinary Diversion Not in Contact with the Fecal Stream: Systematic Review and Meta-analysis

Cited by 4 publications

References 52 publications

Upper Ureteral Reconstruction with a Tapered Descending Colon after Failed Pyeloplasties in a 13-Year-Old Boy

Upper Ureteral Reconstruction with a Tapered Descending Colon after Failed Pyeloplasties in a 13-Year-Old Boy

Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis

Long-term risks of childhood surgery

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