De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

Sponagel, Jasmin; Devarakonda, Siddhartha; Rubin, Joshua B.; Luo, Jingqin; Ippolito, Joseph E.

doi:10.1016/j.isci.2022.105339

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Sex Differences In An Epigenetics-metabolism Cycle1

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Cited by 5 publications

(1 citation statement)

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“…In the context of cancer, this same mediator promotes a permissive transcriptome to promote cellular proliferation ( 114 ). Sex differences in glucose uptake and flux of glucose into de novo serine biosynthesis have been reported in glioblastoma ( 115 ) and lung cancer models ( 116 ), respectively. Expression of de novo serine biosynthesis enzymes is controlled by the ATF4/ATF3 axis.…”

Section: Sex Differences In An Epigenetics-metabolism Cyclementioning

confidence: 99%

Epigenetic developmental mechanisms underlying sex differences in cancer

Rubin,

Abou-Antoun,

Ippolito

et al. 2024

Journal of Clinical Investigation

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Section: Sex Differences In An Epigenetics-metabolism Cyclementioning

confidence: 99%

Epigenetic developmental mechanisms underlying sex differences in cancer

Rubin,

Abou-Antoun,

Ippolito

et al. 2024

Journal of Clinical Investigation

Self Cite

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Female-specific pancreatic cancer survival from CT imaging of visceral fat implicates glutathione metabolism in solid tumors

Ballard,

Nguyen,

Atagu

et al. 2024

Academic Radiology

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Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes

Mironchuk,

Chang,

Rahmani

et al. 2024

Sci Rep

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Clinically, the body mass index remains the most frequently used metric of overall obesity, although it is flawed by its inability to account for different adipose (i.e., visceral, subcutaneous, and inter/intramuscular) compartments, as well as muscle mass. Numerous prior studies have demonstrated linkages between specific adipose or muscle compartments to outcomes of multiple diseases. Although there are no universally accepted standards for body composition measurement, many studies use a single slice at the L3 vertebral level. In this study, we use computed tomography (CT) studies from patients in The Cancer Genome Atlas (TCGA) to compare current L3-based techniques with volumetric techniques, demonstrating potential limitations with level-based approaches for assessing outcomes. In addition, we identify gene expression signatures in normal kidney that correlate with fat and muscle body composition traits that can be used to predict sex-specific outcomes in renal cell carcinoma. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-76280-6.

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De novo serine biosynthesis from glucose predicts sex-specific response to antifolates in non-small cell lung cancer cell lines

Cited by 5 publications

References 58 publications

Epigenetic developmental mechanisms underlying sex differences in cancer

Epigenetic developmental mechanisms underlying sex differences in cancer

Female-specific pancreatic cancer survival from CT imaging of visceral fat implicates glutathione metabolism in solid tumors

Volumetric body composition analysis of the Cancer Genome Atlas reveals novel body composition traits and molecular markers Associated with Renal Carcinoma outcomes

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