Since the tragic death of George Floyd in May 2020, there has been increased interest in anti-racist research. Consequently, several scholars are instigating qualitative inquiries in Black communities with limited preparation or expertise. This article presents a reflection regarding essential principles that can guide general and afro-emancipatory health and social sciences qualitative inquiries in Black diasporas. We contend that it is essential that researchers engage in reflexivity and consider Black ontologies, axiology and epistemologies. Furthermore, we propose the application of the following deontological principles to fulfil an ethical afro-emancipatory research framework: (a) include critical theories, (b) target the liberation of Afro-descendant peoples to enable their full participation as their whole selves in society; (c) ensure their leadership and meaningful involvement throughout the research process; (d) implement accountability mechanisms towards community members; (e) embrace intersectionality, an asset-based lens, and aspirational stance and; (f) foster healing, growth and joy.