De Wied and Colleagues II: Further Clarification of the Roles of Vasopressin and Oxytocin in Memory Processing

McEwen, Barbara B.

doi:10.1016/s1054-3589(04)50003-0

Cited by 6 publications

(8 citation statements)

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“…Considerable evidence from the mid-twentieth century demonstrated that OT and VP affect the process of learning and memory, either directly or indirectly by altering arousal (c.f., McEwen, 2004). The original work in this area focused on the impact of VP and OT in passive or active avoidance learning (Bohus et al, 1972, 1978b; de Wied, 1991), but has also expanded to understanding navigation (i.e., hippocampal-dependent cognition; e.g., Engelmann et al, 1992; Everts and Koolhaas, 1999), retrieval and relearning in visual discrimination (Alescio-Lautier et al, 1987), and social recognition and social memory (e.g., Ferguson et al, 2002; Albers, 2012; Stevenson and Caldwell, 2012).…”

Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

“…The original work in this area focused on the impact of VP and OT in passive or active avoidance learning (Bohus et al, 1972, 1978b; de Wied, 1991), but has also expanded to understanding navigation (i.e., hippocampal-dependent cognition; e.g., Engelmann et al, 1992; Everts and Koolhaas, 1999), retrieval and relearning in visual discrimination (Alescio-Lautier et al, 1987), and social recognition and social memory (e.g., Ferguson et al, 2002; Albers, 2012; Stevenson and Caldwell, 2012). The main neural targets on which VP and OT assert effects on memory include the hippocampus, the cingulate and retrosplenial cortices, septum, several subunits of the thalamus, hypothalamus, and other limbic structures such as the amygdala and medial preoptic area (e.g., Popik and Van Ree, 1998; Ferguson et al, 2001; McEwen, 2004; Ophir et al, 2008b). More recently, increasing attention has been dedicated to understanding the roles of nonapeptides in the hippocampus and hippocampal-dependent memory.…”

Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

“…Much of the evidence has led to the idea that VP and OT appear to have opposite effects on learning and memory, with VP facilitating memory consolidation and retrieval, and OT potentially serving as an amnestic (Bohus et al, 1978a; Kovacs and Telegdy, 1982; Argiolas and Gessa, 1991; de Wied, 1991; McEwen, 2004). For example, nonapeptides are functionally important for social recognition (Gabor et al, 2012).…”

Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

“…Indeed they are well known for their roles in social behavior, pairbonding, and mating systems (Young and Wang, 2004; Carter et al, 2008; Insel, 2010), including in humans (Heinrichs et al, 2009). It is less recognized that they were first studied in behavioral neuroscience for their central effects on memory (de Wied, 1971; Bohus et al, 1978b; Pedersen and Prange, 1979; McEwen, 2004). Somewhat ironically, mating systems are inherently dependent on social and spatial memory.…”

Section: Introductionmentioning

confidence: 99%

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Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions

Ophir

2017

Front. Neurosci.

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The role of memory in mating systems is often neglected despite the fact that most mating systems are defined in part by how animals use space. Monogamy, for example, is usually characterized by affiliative (e.g., pairbonding) and defensive (e.g., mate guarding) behaviors, but a high degree of spatial overlap in home range use is the easiest defining feature of monogamous animals in the wild. The nonapeptides vasopressin and oxytocin have been the focus of much attention for their importance in modulating social behavior, however this work has largely overshadowed their roles in learning and memory. To date, the understanding of memory systems and mechanisms governing social behavior have progressed relatively independently. Bridging these two areas will provide a deeper appreciation for understanding behavior, and in particular the mechanisms that mediate reproductive decision-making. Here, I argue that the ability to mate effectively as monogamous individuals is linked to the ability to track conspecifics in space. I discuss the connectivity across some well-known social and spatial memory nuclei, and propose that the nonapeptide receptors within these structures form a putative “socio-spatial memory neural circuit.” This purported circuit may function to integrate social and spatial information to shape mating decisions in a context-dependent fashion. The lateral septum and/or the nucleus accumbens, and neuromodulation therein, may act as an intermediary to relate socio-spatial information with social behavior. Identifying mechanisms responsible for relating information about the social world with mechanisms mediating mating tactics is crucial to fully appreciate the suite of factors driving reproductive decisions and social decision-making.

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Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

Section: Nonapeptides Monogamy and Memorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions

Ophir

2017

Front. Neurosci.

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“…It convincingly improved LTP and long-term (but not short-term) spatial memory within the eight-arm radial maze task [194]. However, the role of oxytocin on memory storage and retrieval seems not as clear-cut as for vasopressin since its effect depends highly on the type of learning tasks presented, the dose of oxytocin injected and in the case of central administration, the specific brain site injected [197][198][199][200][201][202]. Indeed, in aversive learning situations or in learning contexts based on emotionally arousing and stressful situations, oxytocin exerts amnesic actions [200,202].…”

Section: Mechanism(s) Of Action Of Angiotensin IV Through Interactionmentioning

confidence: 99%

Involvement of insulin-regulated aminopeptidase in the effects of the renin–angiotensin fragment angiotensin IV: a review

et al. 2007

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For decades, angiotensin (Ang) II was considered as the end product and the only bioactive peptide of the renin-angiotensin system (RAS). However, later studies revealed biological activity for other Ang fragments. Amongst those, Ang IV has drawn a lot of attention since it exerts a wide range of central and peripheral effects including the ability to enhance learning and memory recall, anticonvulsant and anti-epileptogenic properties, protection against cerebral ischemia, activity at the vascular level and an involvement in atherogenesis. Some of these effects are AT(1) receptor dependent but others most likely result from the binding of Ang IV to insulin-regulated aminopeptidase (IRAP) although the exact mechanism(s) of action that mediate the Ang IV-induced effects following this binding are until now not fully known. Nevertheless, three hypotheses have been put forward: since Ang IV is an inhibitor of the catalytic activity of IRAP, its in vivo effects might result from a build-up of IRAP's neuropeptide substrates. Second, IRAP is co-localized with the glucose transporter GLUT4 in several tissue types and therefore, Ang IV might interact with the uptake of glucose. A final and more intriguing hypothesis ascribes a receptor function to IRAP and hence an agonist role to Ang IV. Taken together, it is clear that further work is required to clarify the mechanism of action of Ang IV. On the other hand, a wide range of studies have made it clear that IRAP might become an important target for drug development against different pathologies such as Alzheimer's disease, epilepsy and ischemia.

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Developmental trajectories and influences of environmental complexity on oxytocin receptor and vasopressin 1A receptor expression in male and female prairie voles

Prounis

Thomas

Ophir

2018

J of Comparative Neurology

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Nonapeptide receptors, like oxytocin receptor (OTR) and vasopressin 1a receptor (V1aR), modulate a variety of functions across taxa, and mediate phenotypic variation within and between species. Despite the popularity of studying nonapeptides in adults, developmental perspectives on properties of OTR and V1aR expression are lacking. Study of prairie voles (Microtus ochrogaster) has facilitated an understanding of mechanisms of social behavior and provides great potential to inform how early life experiences alter phenotype. We provide the first comprehensive profiling of OTR and V1aR in male and female prairie voles across postnatal development and into adulthood. Differences in receptor densities across the forebrain were region- and sex-specific. Postnatal changes in receptor expression fell into four themes: (a) constant over time, (b) increasing with age, (c) decreasing with age, or (d) peaking during late pre-weaning (postnatal day 15-21). We also examined the influence of post-weaning social and spatial enrichment (i.e., environmental complexity) on OTR and V1aR. Environmental complexity appeared to promote expression of OTR in males and females, and reduced expression of V1aR across several brain regions in males. Our results show that nonapeptide receptor profiles are plastic over development and suggest that different patterns of expression might represent functional differences in sensitivity to nonapeptide activation over a period when social environments are dynamic. Our results on environmental complexity suggest that nonapeptide sensitivity responds flexibly to different environmental contexts during development. Understanding the developmental trajectories of nonapeptide receptors provides a better understanding of the dynamic nature of social behavior and the underlying mechanisms.

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De Wied and Colleagues II: Further Clarification of the Roles of Vasopressin and Oxytocin in Memory Processing

Cited by 6 publications

References 0 publications

Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions

Navigating Monogamy: Nonapeptide Sensitivity in a Memory Neural Circuit May Shape Social Behavior and Mating Decisions

Involvement of insulin-regulated aminopeptidase in the effects of the renin–angiotensin fragment angiotensin IV: a review

Developmental trajectories and influences of environmental complexity on oxytocin receptor and vasopressin 1A receptor expression in male and female prairie voles

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