Deactivation of thalamocortical activity is responsible for suppression of parkinsonian tremor by thalamic stimulation: a 99mTc-ECD SPECT study

Wielepp, J. P.; Burgunder, Jean Marc; Pohle, Thomas; Ritter, Erika; Kinser, J; Krauss, Joachim K.

doi:10.1016/s0303-8467(01)00165-2

Cited by 28 publications

(16 citation statements)

References 23 publications

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“…Multiple PET studies have shown results of decreased activation in the primary sensorimotor areas, SMA, and contralateral cerebellum (Deiber et al 1993;Fukuda et al 2004;Wielepp et al 2001). This is contrary to what is seen in ET and probably relates to the nature of the resting tremor of PD, compared with the action tremor of ET.…”

Section: Effects Of Thalamic Stimulationmentioning

confidence: 96%

“…The difference in DBS effects on response inhibition might be explained by the task employed. For example, improvement was seen with exclusively motor decision making tasks (Mirabella et al 2012;Swann et al 2011;van den Wildenberg et al 2006), while cognitive decision making tasks were associated with a decline in performance (Cavanagh et al 2011;Frank et al 2007). These findings suggest that disrupting the STN locally may affect functionally connected cortical regions via differential effects on two different circuits converging in the STN (Wylie et al 2010).…”

Section: Network Effects Of Subthalamic Nucleus Stimulationmentioning

confidence: 99%

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Network effects of deep brain stimulation

Alhourani

McDowell

Randazzo

et al. 2015

Journal of Neurophysiology

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The ability to differentially alter specific brain functions via deep brain stimulation (DBS) represents a monumental advance in clinical neuroscience, as well as within medicine as a whole. Despite the efficacy of DBS in the treatment of movement disorders, for which it is often the gold-standard therapy when medical management becomes inadequate, the mechanisms through which DBS in various brain targets produces therapeutic effects is still not well understood. This limited knowledge is a barrier to improving efficacy and reducing side effects in clinical brain stimulation. A field of study related to assessing the network effects of DBS is gradually emerging that promises to reveal aspects of the underlying pathophysiology of various brain disorders and their response to DBS that will be critical to advancing the field. This review summarizes the nascent literature related to network effects of DBS measured by cerebral blood flow and metabolic imaging, functional imaging, and electrophysiology (scalp and intracranial electroencephalography and magnetoencephalography) in order to establish a framework for future studies. deep brain stimulation; electrocorticography; magnetoencephalography DEEP BRAIN STIMULATION (DBS) provides a unique opportunity for further understanding of healthy and aberrant human brain function. DBS is the only paradigm in which specific deep brain regions may be manipulated through focal electrical stimulation while simultaneously recording brain activity. An emerging field of study has begun to elucidate how different DBS targets modulate network activity in connected brain regions.

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Section: Effects Of Thalamic Stimulationmentioning

confidence: 96%

Section: Network Effects Of Subthalamic Nucleus Stimulationmentioning

confidence: 99%

Network effects of deep brain stimulation

Alhourani

McDowell

Randazzo

et al. 2015

Journal of Neurophysiology

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“…HF DBS has been developed empirically, and its mechanism is not yet fully understood. Permanent HF stimulation basically mimics the effect of tissue lesioning by suppressing neuronal firing, which in turn suppresses the peripheral tremor (Wielepp et al 2001). HF DBS is reversible and has a much lower rate of side effects than lesioning with thermocoagulation (Schuurman et al 2000).…”

Section: Introductionmentioning

confidence: 99%

A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations

Tass

2003

Biological Cybernetics

434

515

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The coordinated reset of neural subpopulations is introduced as an effectively desynchronizing stimulation technique. For this, short sequences of high-frequency pulse trains are administered at different sites in a coordinated way. Desynchronization is easily maintained by performing a coordinated reset with demand-controlled timing or by periodically administering resetting high-frequency pulse trains of demand-controlled length. Unlike previously developed methods, this novel approach is robust against variations of model parameters and does not require time-consuming calibration. The novel technique is suggested to be used for demand-controlled deep brain stimulation in patients suffering from Parkinson's disease or essential tremor. It might even be applicable to diseases with intermittently emerging synchronized neural oscillations like epilepsy.

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“…The mechanism by which DBS at high frequencies suppresses pathological rhythmic activity has not yet been clarified in detail. The permanent high-frequency stimulation basically mimics the effect of tissue lesioning by suppressing neuronal firing (Benabid et al, 1991(Benabid et al, , 2000Blond et al, 1992;Wielepp et al, 2001). However, permanent high-frequency stimulation is an unphysiological input that may cause an adaptation of the stimulated neuronal networks.…”

Section: Demand-controlled Dbsmentioning

confidence: 99%

Obsessive-Compulsive Disorder: Development of Demand-Controlled Deep Brain Stimulation with Methods from Stochastic Phase Resetting

Tass

Klosterkötter

Schneider

et al. 2003

Neuropsychopharmacol

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Synchronization of neuronal firing is a hallmark of several neurological diseases. Recently, stimulation techniques have been developed which make it possible to desynchronize oscillatory neuronal activity in a mild and effective way, without suppressing the neurons' firing. As yet, these techniques are being used to establish demand-controlled deep brain stimulation (DBS) techniques for the therapy of movement disorders like severe Parkinson's disease or essential tremor. We here present a first conceptualization suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD). In addition, we explain how demand-controlled DBS techniques may be applied to the therapy of OCD in those cases that are refractory to behavioral therapies and pharmacological treatment.

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Deactivation of thalamocortical activity is responsible for suppression of parkinsonian tremor by thalamic stimulation: a 99mTc-ECD SPECT study

Cited by 28 publications

References 23 publications

Network effects of deep brain stimulation

Network effects of deep brain stimulation

A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations

Obsessive-Compulsive Disorder: Development of Demand-Controlled Deep Brain Stimulation with Methods from Stochastic Phase Resetting

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