The study examined the relationship between workplace spirituality and psychosocial safety climate among employees of Indian banks and insurance companies. It also explored the role of gratitude as a moderator in workplace spirituality and psychosocial safety climate. The empirical study measured the following three variables: workplace spirituality, psychosocial safety climate and gratitude. The sample size constituted 317 employees from the Indian banking and insurance sector. The study adopted a regression model that considered three dimensions of workplace spirituality as independent variables and psychosocial safety climate as dependent variables. The relationships between three variables are examined using correlation and multiple regression, and the moderation effect of gratitude is studied using the PROCESS macro in SPSS 21. The results revealed that three dimensions of workplace spirituality are significant predictors of psychosocial safety climate and could explain 61.2% of variations in psychosocial safety climate. It is observed that the workplace spirituality regression weight increases from 0.389 to 0.559 on interacting with gratitude; thus, there is a significant moderating effect of gratitude amid the relationships of three dimensions of workplace spirituality and psychosocial safety climate. Also, if employees display gratuitous behaviour, it will enhance the impact of workplace spirituality on the workplace’s psychosocial safety climate at Indian banking and insurance companies.